Five-month-old boy becomes world's first "3-parent baby"

September 28, 2016

London, Sep 28: Researchers have successfully carried out the process of giving birth to a baby using a controversial "three-parent baby" technique, and the boy has shown no signs of disease by far, the New Scientist, a Britain-based science magazine, reported on Tuesday.

kidThe five-month-old boy is the world's first baby to be born using the technique, which is aimed at assisting parents with rare genetic mutations to have healthy babies, said the magazine.

The boy's mother is a Jordanian who carries genes for Leigh syndrome. It is a fatal disorder affecting the developing nervous system. Around a quarter of her mitochondria have the disease-causing mutation. Leigh syndrome was responsible for the deaths of her first two children, according to the New Scientist.

John Zhang and his team at the New Hope Fertility Center in New York City provided help to the Jordanian couple using the "three-parent baby" technique.

There are different ways of implementing the technique. Britain has approved one of the methods called pronuclear transfer, which involves fertilizing both the mother's egg and a donor egg with the father's sperm. But the couple were against the destruction of two embryos, which would occur when using this method.

So Zhang and his team used another method called spindle nuclear transfer, which removed the nucleus from one of the mother's eggs and inserted it into a donor egg that had had its own nucleus removed. The resulting egg has the nuclear DNA from the mother and mitochondrial DNA from a donor. It was then fertilized with the father's sperm, according to the New Scientist.

Using the spindle nuclear transfer method, Zhang's team created five embryos, only one of which developed normally. That one was implanted in the mother and the child was born nine months later.

Since none of these aforementioned methods has been approved in the United States, the New Hope Fertility Center team had to carry out the whole procedure in Mexico, according to the New Scientist.

The team tested the boy's mitochondria, and found that less than one percent carried the mutation. It is usually deemed that problems will not show unless about 18 percent of mitochondria are affected.

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Agencies
March 25,2020

In an unprecedented crisis despite Prime Minister Narendra Modi assuring the continuation of essential services like food and groceries, online marketplaces like Flipkart and Amazon along with delivery platforms like Bigbasket, Grofers and FreshToHomes hit a major blockade on Wednesday as local authorities shut warehouses and sent delivery boys back, even harassed them.

Millions of people across cities were left helpless at homes as essential items like fruits and vegetables, dairy and milk, meat and fish etc did not reach their doors despite placing orders well in advance. Later, the orders went dry.

While Grofers' warehouse in Faridabad was closed by the local law enforcement agencies, Bigbasket complained that the police stopped its delivery partners and "some of them were even beaten up by for no fault of theirs".

"We are not operational due to restrictions imposed by local authorities on movement of goods in spite of clear guidelines provided by central authorities to enable essential services. We are working with the authorities to be back soon,' Bigbasket tweeted.

In a statement to IANS, Bigbasket said that it will help to have better coordination between the Centre and state, and between the state and local police to "ensure that our delivery vans and bikes don't get stopped by the police. Bigbasket and bb daily are not taking new orders".

Furious people stormed the social media platforms, writing their plight to NITI Aayog CEO Amitabh Kant on Twitter.

"Sir, all e-commerce are down. Believe me I tried everything (Grofers, Bigbasket, Flipkart, Amazon, Big Bazaar), no delivery till 31st March or Server Down or No Service. Need to think how we can enable them through digital India," tweeted one user.

Kant tweeted back to Bigbasket: "They should give me specifics - State & location. I will act on it by getting in touch with concerned authorities & sorting it out. Govt guidelines exempt them. We will ensure that citizens are not impacted".

Kant also responded to Grofers: "Cold storages & Warehouses as well as delivery of all essentials goods including food, pharma thru E-Commerce are exempted under MHA order. I have spoken to CS & DGP, Haryana . They have taken immediate action to ensure that supply chains efficiently function for the citizens".

The subscription-based hyperlocal delivery startup FreshToHome sent messages to its customers, saying that despite the government declaring food delivery as essential, "we are facing hardships in continuing our operations".

"Please bear with us as we are working hard to unblock local authority hurdles," said the FreshToHome team.

Reports later surfaced that the Department for Promotion of Industry and Internal Trade (DPIIT) has initiated talks with the state Chief Secretaries asking them not to restrict movement of people engaged in home delivery of essential items, mentioned in the list of exempted items circulated by the Home Ministry.

Meanwhile, Flipkart said it has temporarily suspended its operations and services - including grocery items. The marketplace has decided to halt all orders from March 25 for all three supply chains -- groceries, non-large goods and large items.

"Flipkart has temporarily suspended orders as we assess the possibilities of operating in the lockdown. We are prioritising the safety of our delivery executives and seeking the support of the local governments and police authorities to meet the needs of our customers as they stay home during this lockdown," Rajneesh Kumar, Chief Corporate Affairs Officer, Flipkart, said in a statement.

E-commerce giant Amazon said the company has to "temporarily stop taking orders and disable shipments for lower-priority products.

"For all pending customer orders on lower-priority products, we are reaching out to customers and giving them a choice to cancel their orders, and receive a refund for prepaid items," said the company.

Witnessing a surge in demand, supermarket chain Biz Bazaar entered the fray, with launching doorstep delivery services in major cities like Delhi, Mumbai, Bengaluru and Gurugram.

However, within no time, Big Bazaar was flooded with calls, forcing the company to issue a statement, saying that "In light of the recent announcement, we are receiving an unprecedented number of requests for doorstep delivery. There could be a delay due to the restrictions on movements".

Already battling massive surge in demand, the online delivery platforms faced other issues too, including zero access to several high-rises across the country which have gone under complete lockdown with all entry and exit gates locked.

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Agencies
August 2,2020

New Delhi, Aug 2: The National Commission for Women (NCW) has issued notice to some Bollywood celebrities named in a complaint against the promoter of a company for allegedly blackmailing and sexually assaulting a number of girls on the pretext of giving them a career in modelling.

Taking cognizance of the complaint filed by social activist Yogita Bhayana of People Against Rape in India (PARI), the NCW scheduled a virtual hearing presided by its chairperson on August 6.

The complaint against Sunny Verma, promoter of a company named IMG Ventures with its headquarter in Chandigarh, alleged that he has been blackmailing and sexually assaulting a number of girls on the pretext of giving them career in modelling.

PARI's Yogita Bhayana wrote a complaint letter to NCW chairperson Rekha Sharma.

"Through his company, he (Sunny Verma) invites the girls on the pretext of organising a Miss Asia contest with a claim that the contest will launch them as models. To make it look genuine, his company has also been taking an entry fee of Rs 2,950. Once the girls apply, they are alluded by the female accomplices of Sunny Verma to submit their nude pictures in order to get the better ranking in the contest," the complaint letter said on July 31.

It alleged that Verma, after receiving the pictures and sometimes even before, used to get in touch with the girls and ask for completely nude pictures and videos.

The complaint letter said that Verma also used to allude as well as threaten the girls to submit to his sexual desires if they were interested in modelling as a career or wish to win the contest.

"Once he established a physical relationship with the girls, he used to blackmail them for regular sexual favours. Many girls from across the country have suffered a sexual and mental assault from Sunny and his accomplices," said the complaint citing several letters, texts and audio clips from several girls as proof of this modus operandi of Sunny Verma and his company.

The complaint also said that Sunny Verma has been previously also arrested on charges of sexual assault.

"We would demand that NCW should investigate the case to its depth and get the guilty punished so that any other person should not dare to exploit these kinds of innocent girls on any pretext. It will be a message to people like Sunny Verma and all associated Bollywood stars. Looking forward to strict action from NCW against sexual offenders like Sunny Verma & others," the complaint said.

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Agencies
February 25,2020

Tokyo, Feb 25: Japan's Chitetsu Watanabe, recognized at 112 years as the oldest man in the world, has passed away 11 days after he received the Guinness World Record certificate, his family said on Tuesday.

Watanabe died on Sunday night, Efe news reported.

He received the official certificate on February 12 at a nursing home in Joetsu in Niigata prefecture, where he resided.

Soon after being certified as the oldest man, he began to experience a lack of appetite and respiratory problems, the wife of his eldest son told public broadcaster NHK.

Born on March 5, 1907 in a family of farmers, Watanabe moved at the age of 20 to Taiwan, where he worked at a sugar refinery for 18 years before returning to Japan after the end of World War II.

A fan of calligraphy, custard and ice cream, Watanabe told the Guinness team that the key to his long life was laughter.

He was recognized as the oldest male in the world following the deaths in 2019 of German Gustav Gerneth (in October), aged 114 years, and Japan's Masazo Nonaka (in January), at the age of 113, three months older than the German.

It remains to be seen who will be recognized after the death of Watanabe, the only male on the list drawn up by the Gerontology Research Group of the 30 oldest people in the world.

Japan has among the highest life expectancy in the world and the number of centenarians in the country has crossed 71,000, according to the latest government figures.

Since 2000, the number of centenarians censored has quintupled, raising concern for the economic outlook and future workforce of the country - where the birthrate is on a downward trend.

Out of these, 88 per cent are women.

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