Here's How IIT Madras Students Are Making Wound Healing Easier For Diabetics

Agencies
May 8, 2018

Students at IIT Madras have developed a novel wound dressing material that would help diabetic patients heal faster. The dressing material uses graphene-based compounds. Wound healing in diabetic is not as rapid as compared to a normal, healthy individual. This delayed healing or non-healed wounds could lead to serious complications and in worse cases call for amputations too. 

In a bid to contribute to the major clinical challenge, students at IIT Madras have come up with a  new wound healing material. The researchers said, that they were aiming to exploit the property of graphene-based materials of improving blood vessel formation at certain concentrations to prepare an inexpensive wound dressing. In the animal studies conducted, the psyllium-reduced graphene oxide nanocomposite showed emphatic results.  

"We hope this is the first step towards developing inexpensive wound dressings using graphene-based materials for clinical use," said Vignesh Muthuvijayan, Assistant Professor, Department of Biotechnology. The researchers used a convex lens to focus sunlight on graphene oxide to obtain reduced graphene oxide. "Thereafter, they loaded these reduced graphene oxide dispersions into a plant carbohydrate polymer (psyllium) solution to obtain wound dressing scaffolds. 

The researchers used fibroblast cells which are responsible for wound healing to evaluate the toxicity and bioactivity of these scaffolds on the cell attachment, migration and proliferation. 

"These newly developed scaffolds provide a suitable tissue-friendly environment for cells and subsequently improve cell proliferation and attachment," Muthuvijayan added.
 
The trials and results revealed that the normal wounds treated with the dressings healed in 16 days as compared to 23 days in untreated normal wounds. Similarly, diabetic wounds treated with the dressings healed in 20 days as against 26 days in untreated diabetic wounds. "These scaffolds are easy to prepare, inexpensive, and show excellent healing properties. Thus, the material acts as a good wound dressing and helps in accelerated healing of normal and diabetic wounds," he said.

Diabetes refers to a group of diseases that result in too much sugar in the blood (high blood glucose). The sugar spike is due to an impaired insulin hormone, that triggers abnormal metabolism of carbohydrate and hike in sugar levels. Your diet and nutrition can play a significant role in managing diabetes. Here are some healthy dietary tips you should make part of your daily regime now.

Follow a balanced diet with complex carbs: According to Preeti Rao, Health and Wellness Coach, eating a variety of fruits and vegetables, lean protein and good sources of fat is very essential for diabetes management. One must avoid trans fats (also called hydrogenated fat), processed food, and sugar and up intake of complex carbs. Complex carbohydrates are rich in fiber and are not highly processed like refined carbohydrates. They take longer to digest and hence provide a sustained source of energy for a longer duration.

Include more Low GI Foods: Glycemic Index (GI) is a relative ranking of carbohydrate in foods according to how they affect blood glucose levels. Carbohydrates with a low GI value (55 or less) are more slowly digested, absorbed and metabolised and cause a lower and slower rise in blood glucose. Low GI foods are also rich in fibre which takes the longest to digest, make you feel fuller for a longer time and help control appetite. This could further help in weight management. Tomato, spinach, guavas, cauliflower, and pears are some low glycemic index foods you can choose to add to your diet.

Avoid Sugary Drinks and Fruit Juices: Diabetics should steer clear of aerated and sugary drinks, various studies and reports have time and again reinforced that these drinks are full of liquid calories and can cause major spike in the blood sugar levels. Your can of fruit juice is not one of the healthiest substitutes either. Fruit juices especially packaged fruit juices are loaded with fructose that elevates the blood sugar levels. It is advisable to eat whole fruits instead. Fruits are full of fibres, fibres take time to metabolise and thus doesn't result in sudden surge in blood sugar levels. Eat fruits that have a low glycemic index. Eat fruits with some nuts and olives to balance the glycemic load.

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Agencies
May 23,2020

Food with high water content is highly prescribed by doctors to stay hydrated during the summers, a season that summons a wave of soaring temperatures, higher than 40-degrees.

A much-loved fruit in India, apples are hydrating heros' in such a situation. A heatwave can affect human health in a varied manner and to maintain ideal body temperature in this soaring summer, one must remain adequately hydrated, be protected from the sun and maintain hygiene.

Working professionals and people who must step out in summers, are prone to the heatwave impact. Pediatric experts and doctors agree on the benefits of drinking water and eating fruits, especially, apples. 'An apple a day, keeps the doctor away' is true as they are rich in a number of vitamins with great anti-inflammatory benefits and many other essential minerals. Washington Apple Commission spells how apples can prove to be a summer-friendly fruit.

People often don't realise the danger of exposing themselves to extreme heat. Older adults, young children, and people with chronic illnesses are most at greater risk for serious problems. The nutrition benefits of apples may help not only in avoiding such illnesses but may also protect against many such conditions.

As popular as apples are as a fruit, they are enriched in antioxidants, dietary fibers, vitamins and a range of other nutrients that are greatly beneficial in maintaining good health. The fruit is rich in soluble fibers which may help prevent several health conditions and may lower the risk of major diseases such as heat strokes, diabetes and cancer.

The soluble fiber also promotes weight loss and improves gut health. The prebiotic effects of apples help feed the good bacteria in the gut, thus, improving digestion.

Apples are made of 85 percent water and contain vitamins, fibres and antioxidants. A high fibre content is a particularly beneficial property of apples, as improper digestion is a major health concern in the tropical climatic region. Apples are also enriched in antioxidants that help protect the lungs from oxidative damage and help oxygen flow through the blood.

Apple-based recipes

Make interesting snacks, dessert, beverages and savoury meals with this miraculous fruit during summers.

Salted apple caramel galette

Caramel apples get a grown-up makeover with this Salted Caramel Apple Galette. Warm, gooey, and delicious, this pastry is loaded with apples and homemade caramel. It's a sophisticated take on a childhood favorite and since it's easier to make than pie, it's perfect for summer get-togethers.

Caramel apple pie ice-cream sandwiches

Nothing is better at a cookout on a warm day than a cold, refreshing ice cream sandwich. In Caramel Apple Pie Ice Cream Sandwiches, the comforting flavor of apple pie is recreated in a creamy frozen banana-based ice cream studded with apple and date pieces. Then that scoop of ice cream is sandwiched between two pieces of no-bake cinnamon oat cookie dough.

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Agencies
February 6,2020

Researchers have found the rates of lung cancer are higher in young women than men.

The study, published in the journal Pediatrics, examined lung cancer rates in young adults in 40 countries across five continents and uncovered a trend of higher lung cancer rates in women compared with men in recent years.

The emerging trend was widespread, affecting countries across varied geographic locations and income levels.

The changes appeared to be driven by a rising rate of adenocarcinoma lung cancer among women, said the study researchers from University of Calgary in Canada.

Lung cancer rates have been higher among men than women because men started smoking in large numbers earlier and smoked at higher rates; however, recent studies have reported converging lung cancer incidence rates between sexes.

Among men, age specific lung cancer incidence rates generally decreased in all countries, while in women the rates varied across countries with the trends in most countries stable or declining, albeit at a slower pace compared to those in men.

For the findings, lung and bronchial cancer cases between 30-64 age group from 1993-2012 were extracted from cancer incidence in five continents.

The study found the higher emerging rates of lung cancer in young women compared to young men.

According to the researchers, future studies are needed to identify reasons for the elevated incidence of lung cancer among young women.

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News Network
February 22,2020

Feb 22: The subjective feeling of well-being experienced by many people with the practice of meditation is associated with specific changes in the brain, according to a study which may lead to better clinical recommendations of the practice.

The study, published in the journal Brain and Cognition, examined the effects of the technique known as Transcendental Meditation (TM), which consists of the silent repetition of a meaningless sound.

In the study, the researchers from the IMT School for Advanced Studies Lucca in Italy, enrolled 34 healthy young volunteers and divided them in two groups.

They said the first group practised TM 40 minutes per day in two sessions of 20 minutes each, one in the morning and the other in the evening.

The second group, the scientists said, did not change its daily routine.

Using questionnaires, they also measured the anxiety and stress levels of all the participants at the beginning of the study, as well as the subjects' ability to manage stressful situations.

According to the researchers, the participants were also subjected to a functional magnetic resonance imaging (fMRI) brain scan, in order to measure the organ's activity at rest, and changes in the excitation among different cerebral areas.

They repeated the tests after three months, at the end of the study.

According to the study, the levels of anxiety and stress perceived by the subjects who followed the meditation program were significantly reduced in comparison with those of the volunteers who did not practice TM.

"Magnetic resonance imaging also shows that the reduction of anxiety levels is associated with specific changes in the connectivity between different cerebral areas, such as precuneus, left parietal lobe and insula, which all have an important role in the modulation of emotions and inner states," said study co-author Giulia Avvenuti from the IMT School for Advanced Studies Lucca.

"In the control group, instead, none of these changes was observed. The fact that Transcendental Meditation has measurable effects on the 'dialogue' between brain structures involved in the modulation of affective states opens new perspectives for the understanding of brain-mind relationships," said Pietro Pietrini, IMT School's Director, and co-author of the study.

"It also extends the results of recent research suggesting that drugs therapies and psychotherapy leverage on the same biological mechanism," Pietrini said.

According to the researchers, even a few months of practice of TM can have positive effects which can be correlated with measurable changes in the brain.

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