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Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.

Bengaluru, July 13: Chief Minister B S Yediyurappa on Monday made it clear that the government had no plans to extend the lockdown in Bengaluru Urban and Bengaluru Rural districts beyond July 22.  The two districts will enter a lockdown starting 8 pm on July 14. 

“There is no proposal before the government to extend the lockdown in Bengaluru Urban and Rural districts. The chief minister requests citizens not to panic and cooperate with the government without paying heed to rumours,” the Chief Minister’s Office (CMO) said. 

“The lockdown is being imposed to control the rising number of Covid-19 cases in these districts. The CM has instructed officials to make all arrangements in a week’s time and make ready whatever is necessary,” the CMO said. 

The clarification came after Yediyurappa chaired a meeting of the Covid-19 task force meeting. Yediyurappa also held a video conference with officials from all districts to review the Covid-19 situation, rainfall and irrigation measures. 

Two more districts - Dakshina Kannada and Dharwad - have decided to impose a lockdown to control the spread of Covid-19 following Yediyurappa’s video conference. Starting July 15, Dakshina Kannada will be under a lockdown for a week whereas it will be a 9-day lockdown in Dharwad. 

During his video conference, Yediyurappa noted that the number of cases was on the rise in Bengaluru, Dakshina Kannada, Dharwad, Ballari, Udupi and Kalaburagi. 

He further noted that Covid-19 fatalities were going up in Bidar, Dharwad, Gadag and Mysuru. He asked authorities to bring this under control. “Bidar is among five districts nationally when it comes to deaths. This has to be controlled,” Yediyurappa said, seeking a report by experts on this. 

Yediyurappa told authorities to prioritize rapid antigen tests. “One lakh test kits have been procured. Use them wisely in emergency cases,” the CM said. He ordered that those aged above 60 years, those with serious illnesses and showing symptoms of influenza-like illness (ILI) have to be identified and subjected to Covid-19 tests.