If you want me to continue as DyCM then vote for disqualified MLA: Laxman Savadi to voters

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Bengaluru, Jul 21: Leader of Opposition and former Chief Minister of Karnataka Siddaramaiah on Monday attacked the ruling government and said press conference of Health Minister B Siramulu was more like an exercise to hide facts than presenting proof with accurate data.

"Got to know about the press conference addressed by B Siramulu and Dr Ashwathnarayan CN to clear accusations of corruption. It looked more like an exercise to hide facts than presenting proof with accurate data," Siddaramaiah tweeted.

"It is still unclear about the points presented in the press conference. They have not answered any of my questions which were raised earlier. I will respond in detail once I receive the written explanation from the govt. Minister has claimed that both Health & Medical education department together have spent Rs323 Cr. But the data presented by them does not even add up to Rs100 Cr. What happened to the rest of the money?," asked Siddaramaiah.

He said that Centre has procured ventilators at Rs4 lakh per unit under PM Cares. But only in our state, the ventilators are procured at Rs12-Rs18 lakh per unit

"Prime Minister's Office has procured ventilators at Rs4 lakh per unit under PM Cares. But only in our state, the ventilators are procured at Rs12-Rs18 lakh per unit. Why do we see such a huge difference in price? Ministers, in the press conference, have told that quality & technological capabilities are the reasons for huge price difference. Does it mean ventilators under PM Cares lack quality? Why did they not present the technical specifications to justify the same?" he asked.

"Not just about the procurement of medical equipment, I had even asked data about food kits, PDS distribution, beds procured, quarantine centres & isolation wards. Where is the data for that?" he asked in a series of tweets. 

Dharward, Jul 25: In a shocking incident, a man reportedly killed his wife and daughter by feeding them poison and ended his life by hanging in his house. The incident took place in Dharwad on Saturday. 

The deceased have been identified as Mounesh Pattar (36), his wife Arpita (28) and their four-year-old daughter Sukruta. 

Mounesh was working in a private company in Dharwad and was depressed from the last one week fearing job loss. 

It was alleged that he might lose his job as the management decided to remove more than 40 employees due to covid -19 lockdown.

On Friday late night, he reportedly gave poison to his wife and daughter and later committed suicide by hanging self. The incident came to light on Saturday morning.

A case is registered at Sub Urban police station and further investigation is on.