Indian-American teen wins top science award worth USD 250,000

March 16, 2017

Washington, Mar 16: An Indian-American teen has won the top award, worth USD 250,000, in the oldest and most prestigious science and math competition in the US, for her research on preventing death of neurons due to brain injuries or neurodegenerative diseases.

American

Indrani Das, a 17-year-old resident of New Jersey, and four other Indian-origin students were among the top ten finalists to be honoured at the annual Regeneron Science Talent Search Awards Gala for their research projects demonstrating exceptional scientific and mathematical ability.

Forty finalists took home more than USD 1.8 million in awards.A contributor to neuron death is astrogliosis, a condition that occurs when cells called astrocytes react to injury by growing, dividing and reducing their uptake of glutamate, which in excess is toxic to neurons.

In a laboratory model, Das showed that exosomes isolated from astrocytes transfected with microRNA-124a both improved astrocyte uptake of glutamate and increased neuron survival.

Arjun Ramani, an 18-year-old student from Indiana won the third place honours worth USD 150,000 for blending the mathematical field of graph theory with computer programming to answer questions about networks.

Typically, these questions require statistical comparisons to hundreds or thousands of random graphs, a process that can take a relatively long time.

He developed an algorithm that greatly accelerated the process by reducing the time required to generate these graphs.

"Congratulations to the Regeneron Science Talent Search 2017 top winners," said George D Yancopoulos, President and Chief Scientific Officer of Regeneron.

"My experience as a Science Talent Search winner led me to embark on a career in science, and I hope it will inspire these exceptional young scientists to become the next generation of innovators that will improve the world and solve some of our most pressing challenges as a society," said Yancopoulos.

Archana Verma, 17, from New York, received a USD 90,000 award for her study of the molecular orbital energy dynamics of dyes, which may someday result in windows that produce solar energy.

Prathik Naidu, 18, from Virginia, received a USD 70,000 award for his creation of a new machine learning software to study 3D interactions of the human genome in cancer.

Vrinda Madan, 17, from Florida, received a USD 50,000 award for her study of 24 potential compounds for the treatment of malaria, in which she found two potential candidates that appear to target the disease-causing organism in a novel way and may warrant further study.

Of more than 1,700 high school seniors who entered the Regeneron Science Talent Search 2017, roughly 300 were named scholars in January.

Of those scholars, 40 students were named finalists and invited to Washington, DC to compete for the top 10 awards.

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News Network
May 2,2020

Balochistan, May 1: Sajid Hussain, Editor-in-Chief of Balochistan Times, has been found dead in a Swedish town, the police have confirmed.

The Swedish police informed his family on Thursday night that they discovered his body from a river in Uppsala, The Times reported.
The Baloch journalist had been missing from the Swedish city since March 2 this year.

Sajid, 39, left Pakistan in 2012 and had been living as a refugee in Sweden since 2017. He wrote extensively on the suffering of the Balochis at the hands of the Pakistani military establishment.

His work often got him into trouble as the authorities did not like his reporting of Balochistan's forbidden stories, the reason he had to leave and live in exile.

The Baloch journalist was found dead two months after he went missing in Sweden.
Sajid left Pakistan because of security threats from Pakistan Army and its intelligence service ISI.

The spokesperson of the Baloch National Movement, Hammal Haider told news agency: "We are deeply saddened by the demise of prominent Baloch intellectual and writer Sajid Hussain."
"His death is indeed a loss of a great mind for the people of Balochistan. Due to his straightforwardness, he was loved among all journalistic, literary and political circles," added Haider.

"After this incident, we have serious concerns about our members and other Baloch refugees living in the West," he said.

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Agencies
March 28,2020

Canadian researchers are developing a DNA vaccine for SARS-CoV-2, the coronavirus that causes COVID-19 and has currently infected nearly 5,00,000 people worldwide and crippled the global economy.

Entos Pharmaceuticals, a health-care biotechnology company headed by a University of Alberta researchers, develop new therapeutic compounds using the company's proprietary drug-delivery platform and has begun manufacturing vaccine candidates against the novel coronavirus.

"Given the urgency of the situation, we can have a lead candidate vaccine within two months. Once we have that it's a race to get it into clinical trials," said John Lewis, CEO of Entos and a Professor at the University of Alberta in Canada.

Lewis said in comparison to a traditional vaccine, DNA-based vaccines hold several advantages.

Nucleic acids are introduced directly into the patient's own cells, causing them to make pieces of the virus--tricking the immune system into mounting a response without the full virus actually being present, the researcher said.

According to the company, the approach is recognised as being easier to move into large-scale manufacturing, offers improved vaccine stability and works without needing an infectious agent.

In the current absence of a vaccine for COVID-19, several companies around the world are mounting efforts to begin similar work.

The first clinical trial using a DNA-based vaccine developed by Moderna Inc.in the US on March 13.

Their approach allows for antibodies to be made in the human trial volunteers against a specific protein on the surface of the coronavirus that lets the virus enter human cells.

The hope is that the antibodies will stop the interaction.

Though this approach is designed to be effective against COVID-19 specifically, Lewis said Entos is taking a different tack.

The company plans to use plasmid DNA to amplify the production of key coronavirus surface and structural proteins with each injection, with an eye to the bigger picture.

"Many of the structural proteins in the virus are pretty well conserved across all the coronaviruses, including SARS and MERS," said Lewis.

"We're hoping that if we express more of the structural proteins that are common to most coronaviruses, we can inhibit the current COVID-19, and also potentially protect against all coronaviruses both past and future," Lewis added.

To move the project forward quickly, the company is seeking financial support from both provincial and federal levels of government.

"We have the opportunity to save a lot of lives, and I think it's really upon us and governments to find solutions for that," Lewis said.

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News Network
January 10,2020

Washington, Jan 10: It is “highly likely” that Iran shot down the civilian Ukrainian jetliner that crashed near Tehran late Tuesday, killing all 176 people on board, U.S., Canadian and British officials declared Thursday.

They said the fiery missile strike could well have been a mistake amid rocket launches and high tension throughout the region.

The crash came just a few hours after Iran launched a ballistic attack against Iraqi military bases housing U.S. troops in its violent confrontation with Washington over the U.S. drone strike that killed an Iranian Revolutionary Guard general. The airliner could have been mistaken for a threat, said four U.S. officials, speaking on condition of anonymity to discuss sensitive intelligence.

Canadian prime minister Justin Trudeau, whose country lost at least 63 citizens in the downing, said in Toronto: “We have intelligence from multiple sources including our allies and our own intelligence. The evidence indicates that the plane was shot down by an Iranian surface-to-air missile.”

Likewise, U.K. prime Minister Boris Johnson and Australian prime minister Scott Morrison offered similar statements. Morrison also said it appeared to be a mistake. “All of the intelligence as presented to us today does not suggest an intentional act,” he said.

The assessment that 176 people were killed as collateral damage in the Iranian-U.S. conflict cast a new pall over what had at first appeared to be a relatively calm aftermath following the U.S. military operation that killed Iranian Gen. Qassem Soleimani.

At the White House, U.S. president Donald Trump suggested he believed Iran was responsible for the shootdown and dismissed Iran's initial claim that it was a mechanical issue with the plane.

“Somebody could have made a mistake on the other side.” Trump said, noting the plane was flying in a “pretty rough neighborhood."

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