Machine Learning model developed to identify bat species that can spread Nipah

Agencies
June 29, 2019

Researchers have developed a model using Machine Learning (ML) to identify bat species with the potential to host the Nipah virus, with a focus on India. Four new bat species were flagged as surveillance priorities.

"While there is a growing understanding that bats play a role in the transmission of Nipah virus in Southeast Asia, less is known about which species pose the most risk. 

"Our goal was to help pinpoint additional species with a high likelihood of carrying Nipah, to target surveillance and protect public health," said Barbara Han from Cary Institute of Ecosystem Studies in the US. 

India is home to an estimated 113 bat species. Just 31 of these species have been sampled for the Nipah virus, and 11 have been found to have antibodies that signal host potential, according to the study published in the journal PLOS Neglected Tropical Diseases.

The Nipah virus is a highly lethal, emerging henipavirus that can be transmitted to people from the body fluids of infected bats. Eating fruit or drinking date palm sap that has been contaminated by bats has been flagged as a transmission pathway. Domestic pigs are also bridging hosts that can infect people.

Once infected, people can spread the virus directly to other people, sparking an outbreak. There is no vaccine and the virus has a high mortality rate.

For the study, Machine Learning, a form of Artificial Intelligence, was used to flag bat species with the potential to harbour Nipah. 

"By looking at the traits of bat species known to carry Nipah globally, our model was able to make predictions about additional bat species residing in India with the potential to carry the virus and transmit it to people. These bats are currently not on the public health radar and are worthy of additional study," Han said.

For the study, the research team compiled published data on bat species known to carry Nipah and other henipaviruses globally. 

Data included 48 traits of 523 bat species, including information on foraging methods, diet, migration behaviours, geographic ranges and reproduction. 

During the study, their algorithm identified known Nipah-positive bat species with 83 per cent accuracy. 

It also identified six bat species that occur in Asia, Australia and Oceania that have traits that could make them competent hosts and should be prioritised for surveillance. Four of these species occur in India, two of which are found in Kerala.

"We set out to make trait-based predictions of likely henipavirus reservoirs near Kerala. Our focus was narrow, but the model was successful in identifying Nipah hosts, demonstrating that this method could serve as a powerful tool in guiding surveillance for Nipah and other disease systems," said Raina K. Plowright from Montana State University in the US.

"Identifying which species harbour disease is an important first step in surveillance planning. We also need to prioritise research on which virus strains pose the greatest risk to people. Ultimately, the goal is to extinguish risk, not fight fires," Han concluded.

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Agencies
August 2,2020

Washington, Aug 2: Children under the age of five have between 10 to 100 times greater levels of genetic material of the coronavirus in their noses compared to older children and adults, a study in JAMA Pediatrics said Thursday.

Its authors wrote this meant that young children might be important drivers of Covid-19 transmission within communities -- a suggestion at odds with the current prevailing narrative.

The paper comes as the administration of US President Donald Trump is pushing hard for schools and daycare to reopen in order to kickstart the economy.

Between March 23 and April 27, researchers carried out nasal swab tests on 145 Chicago patients with mild to moderate illness within one week of symptom onset.

The patients were divided into three groups: 46 children younger than five-years-old, 51 children aged five to 17 years, and 48 adults aged 18 to 65 years.

The team, led by Dr Taylor Heald-Sargent of the Ann & Robert H. Lurie Children's Hospital, observed, "a 10-fold to 100-fold greater amount of SARS-CoV-2 in the upper respiratory tract of young children."

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The authors added that a recent lab study had demonstrated that the more viral genetic material was present, the more infectious virus could be grown.

It has also previously been shown that children with high viral loads of the respiratory syncytial virus (RSV) are more likely to spread the disease.

"Thus, young children can potentially be important drivers of SARS-CoV-2 spread in the general population," the authors wrote.

"Behavioral habits of young children and close quarters in school and daycare settings raise concern for SARS-CoV-2 amplification in this population as public health restrictions are eased," they concluded.

The new findings are at odds with the current view among health authorities that young children -- who, it has been well established, are far less likely to fall seriously ill from the virus -- don't spread it much to others either.

However, there has been fairly little research on the topic so far.

One recent study in South Korea found children aged 10 to 19 transmitted Covid-19 within households as much as adults, but children under nine transmitted the virus at lower rates.

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Agencies
May 25,2020

Singapore, May 25: COVID-19 patients are no longer infectious after 11 days of getting sick even though some may still test positive, according to a new study by infectious disease experts in Singapore.

A positive test "does not equate to infectiousness or viable virus," a joint research paper by Singapore's National Centre for Infectious Diseases and the Academy of Medicine, Singapore said. The virus "could not be isolated or cultured after day 11 of illness."

The paper was based on a study of 73 patents in the city-state.

The latest findings may have implications on the country's patient discharge policy. The discharge criteria is currently based on negative test results rather than infectiousness.

Singapore's strategy on managing COVID-19 patients is guided by the latest local and international clinical scientific evidence, and the Ministry of Health will evaluate if the latest evidence can be incorporated into its patient clinical management plan, according to a report by the Straits Times.

So far, 13,882, or about 45% of the total 31,068 Covid-19 patients in Singapore have been discharged from hospitals and community facilities. Singapore reported 642 new Covid-19 cases as of noon on Saturday.

The government has been actively screening pre-school staff as it prepares to reopen pre-schools from June 2. On Friday, two pre-school employees tested positive for the novel coronavirus, bringing the total number of confirmed cases among pre-school staff to seven, according to the Ministry of Health.

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Agencies
May 6,2020

Washington D.C., May 5: Working from home has become the new normal ever since the outbreak of coronavirus and in today's time the work duties can be easily dealt with by means of mobile devices at home.

However, this easy use of technology, mobile devices for that matter, has the potential to blur the fine line between work and the other daily life routines.

But, contrary to the belief, a study at the University of Jyvaskyla reveals that the mixing of work and other daily life routines may have more benefits than previously assumed, and points to the importance of boundary-spanning communication.

A smartphone enables phone calls, email, and file transfers from the comfort of home. The study shows that there may be more effective ways to maximise the benefits of smartphone use, without diminishing employees' flexibility and the use of these technologies.

"People often forget to talk about positive effects, such as autonomy and freedom the employees gain when they have the flexibility to schedule their work," said Postdoctoral Researcher Ward van Zoonen from JYU, who with his colleagues examined the use of smartphones for work matters outside working hours.

The study paid special attention to the benefits of talking about domestic matters with the immediate supervisor outside the working hours given to an employee.

"This reduces the conflict between work and other life," van Zoonen said.

"If people in an organisation strive for more dialogue between employees' different life domains, it is possible to create a functional environment where people can talk about different matters."

The research findings show that when employees communicate across boundaries and talk at work about their life in other respects, they can receive new kinds of support and understanding from their immediate supervisor.

"This kind of communication creates a low threshold for contacting one's supervisor, which helps employees build a balance between the different domains of their lives and strengthens their organisational identification," said Professor Anu Sivunen describing the findings.

This means that tight working time restrictions to protect employees might not be beneficial after all, if they hinder reaching the positive results indicated in this research.

For the study, a survey was taken of 367 employees who were asked questions such as -- how much they talk about their work with their family, and how much they talk about their family with their immediate supervisor.

"Both supervisors and their employees answered the surveys, and the study actually focused on their mutual communication," Sivunen said.

"Usually people at workplaces are interested in how communication within the work community is succeeding. It is often forgotten how an immediate supervisor can take an employer's other life into account and thereby help the employee gain work-related benefits."

"Communication with one's immediate supervisor during flexible working hours, also on matters other than work, could ease the daily lives of many employees if they could share the possible challenges of their family life or free time with their supervisor in these settings," Sivunen added.

According to the study, such a practice could make the supervisor aware of the employee's situation as he/she works from home and the related impacts on their work performances.

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