Maggots ate organs of Indian toddler, US doctor unable to perform autopsy

Agencies
June 27, 2019

Houston, Jun 27: When the body of 3-year-old Indian toddler Sherin Mathews reached the morgue, maggots had eaten her internal organs, the doctor who performed the autopsy on the toddler in 2017 has told jurors in Dallas, Texas.

The Indian-American foster father of Sherin, Wesley Mathews, in an unexpected move, pleaded guilty on Monday to injury to a child by omission, a lesser charge, at the start of what was supposed to be his capital murder trial.

On the second day of the trial on Tuesday, 39-year-old Mathews said in a testimony that he raised his voice at Sherin while he was trying to get her to drink her milk in the garage. That startled her, and she began to choke on the milk.

He initially claimed that as punishment for not drinking her milk he sent Sherin outside at 3 am to stand by a tree outside the backyard of their home in Richardson, Texas. When he checked in on her 15 minutes later, Mathews said Sherin was missing.

Two weeks later, when Sherin’s body was found in a nearby culvert by a cadaver dog, Mathews changed his story, claiming he “physically assisted” his adopted daughter in drinking the milk and that the toddler choked.

Mathews and his wife Sini Mathews, both from Kerala, adopted Sherin (born as Saraswati) from an orphanage in Bihar in 2016.

Dr Elizabeth Ventura, the forensic pathologist who performed Sherin’s autopsy in October 2017, testified on Tuesday about her conclusions in the toddler’s death.

Ventura said she could not determine how Sherin died as the body was too decomposed to get an official cause of death.

She told the jurors -- four women and eight men -- that maggots had eaten Sherin’s internal organs away as her body was discovered in a trash bag in a culvert two weeks after her death. Ventura said that due to the decomposition of the child’s vital organs like the heart and lungs, she was unable to perform an internal autopsy and determine her cause of death.

Complicating the issue of determining how Sherin died was the absence of other evidence, including the clothes that Mathews washed before calling to report his daughter missing.

Sherin’s body was too decomposed to determine any other medical conditions at the time of her death, she said.

She ruled the manner of Sherin’s death “homicidal violence” due to the circumstances surrounding the case, Ventura told the jurors.

The pathologist also did not agree with the claim of Mathews that Sherin choked to death on milk.

“It’s not a cause of death that I have run across,” said Ventura. “We have yet to have a case where a child died from drinking milk,” she told the jury.

Apart from Dr Ventura, authorities testified that there were many red flags surrounding Mathews that made them believe Sherin was murdered.

According to Suzanne Dakil of the Referral and Evaluation of At Risk Children Clinic (REACH), Sherin was deficient in Vitamin D, had scurvy, and showed signs of physical abuse.

Dakil testified the Sherin had five broken bones within eight months. Authorities said Mathews’ casual and uncaring attitude, coupled with other evidence and information, was enough for them to charge him with capital murder.

Mathews still faces life in prison and prosecutors urged the jury on Monday to choose that sentence. The jury could decide on a lighter sentence, US media reports said.

In his testimony, Mathews said fear prevented him from asking for help, even from his wife, Sini, a registered nurse. At first, he hoped Sherin would be revived if he prayed hard enough. For a second, he said, he wanted a venomous snake to jump from the culvert and bite him so he could be with the toddler again.

He said he acted alone because he was terrified that his wife or his other daughter would see Sherin lifeless and that Child Protective Services would get involved.

“I keep going over and over again back to that night and I keep asking myself why was I being driven by fear,” Mathews said. “I was just completely driven by fear, and I can’t imagine that level of stupidity I went to driven by fear,” Mathews was quoted as saying by the Dallas Morning News.

Mathews said he then decided to try to find a place where he could protect her body, preserving her until he could give her a proper burial.

“I refused to believe that my child had completely gone from the world,” Mathews testified on Tuesday. He said he believed if he “prayed hard and strong enough” Sherin might be resurrected, like Lazarus. Police charged Sherin’s foster monther Sini with child abandonment in November 2017, after her husband told officials the couple left Sherin alone the night of her death while they went to dinner with their biological daughter. Sini’s case was dismissed in March this year after prosecutors said they could not prove it beyond a reasonable doubt.

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News Network
April 10,2020

Melbourne, Apr 10: Scientists have identified six drug candidates from more than 10,000 compounds that may help treat COVID-19.

The research, published in the journal Nature, tested the efficacy of approved drugs, drug candidates in clinical trials and other compounds.

"Currently there are no targeted therapeutics or effective treatment options for COVID-19," said Professor Luke Guddat from the University of Queensland in Australia.

"In order to rapidly discover lead compounds for clinical use, we initiated a programme of high-throughput drug screening, both in laboratories and also using the latest computer software to predict how different drugs bind to the virus," Guddat said.

The project targeted the main COVID-19 virus enzyme, known as the main protease or Mpro, which plays a pivotal role in mediating viral replication, the researchers said.

This makes it an attractive drug target for this virus, and as people don't naturally have this enzyme, compounds that target it are likely to have low toxicity, they said.

"We add the drugs directly to the enzyme or to cell cultures growing the virus and assess how much of each compound is required to stop the enzyme from working or to kill the virus. If the amount is small, then we have a promising compound for further studies," said Guddat.

After assaying thousands of drugs, researchers found of the six that appear to be effective in inhibiting the enzyme, one is of particular interest.

"We're particularly looking at several leads that have been subjected to clinical trials including for the prevention and treatment of various disorders such as cardiovascular diseases, arthritis, stroke, atherosclerosis and cancer," Guddat said.

Researchers said compounds that are already along the pipeline to drug discovery are preferred, as they can be further tested as antivirals at an accelerated rate compared to new drug leads that would have to go through this process from scratch.

"With continued and up-scaled efforts we are optimistic that new candidates can enter the COVID-19 drug discovery pipeline in the near future," Guddat said.

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News Network
March 25,2020

Beijing, Mar 25: Around 5,000 people have signed up for the phase I clinical trial of recombinant novel coronavirus vaccine in Chinese city Wuhan where the virus first emerged late last year.

The recruitment for participants ended this week with nearly 5,000 volunteers signing up for the trial, state-run Beijing News reported on Wednesday.

A single-centre, open and dose-escalation phase I clinical trial for recombinant novel coronavirus vaccine (adenoviral vector) will be tested in healthy adults aged between 18 and 60 years, according to the ChiCTR (China Clinical Trial Register).

The trial, led by experts from the Academy of Military Medical Sciences, gained its approval on March 16 and the research is expected to last half a year.

Requiring at least 108 participants, the trial will be conducted in Wuhan, capital of Hubei province, the region worst-affected by the virus in the country, state-run China Daily reported.

Participants will experience 14-day quarantine restrictions after being vaccinated and their health condition will be recorded every day.

Chinese scientists are hastening the development of COVID-19 vaccines through five approaches --- inactivated vaccines, genetic engineering subunit vaccines, adenovirus vector vaccines, nucleic acid vaccines and vaccines using attenuated influenza virus as vectors.

So far, most teams are expected to complete preclinical research in April and some are moving forward faster, Wang Junzhi, an academician with the Chinese Academy of Engineering said.

Wang noted that research and development of COVID-19 vaccines in China is not slower than foreign counterparts and has been carried out in a scientific, standardised and orderly way.

China has stepped up the process to finalise vaccines to counter COVID-19 after Kaiser Permanente research facility in Seattle and Washington stole the march and began human trials.

China lifted tough restrictions on the Hubei province on Wednesday after a months-long lockdown as the country reported no new domestic cases.

But there were another 47 imported infections from overseas, the National Health Commission said. In total, 474 imported infections have been diagnosed in China -- mostly Chinese nationals returning home.

Comments

Y UDAYA CHANDAR
 - 
Monday, 13 Apr 2020

Dear Sir,

 

I am 77 but a very healthy person with remarkable immunity. I contracted Malaria fever in 1994 because of mosquito biting and I have not been sick anytime there after, not even for ordinary fever in the last 26 years.

 

I am sure you would like to conduct the trials on persons of varying criteria. I am sure you don't want to carry out the trials on perfectly healthy young individuals only. 

 

I am certain that  you want to try the vaccine on a 'common man' from 'general public.' I am ready for the trial and you can take me. I will be delighted. 

 

If you are not handling this matter kindly forward this mail to the correct agency.

 

I look forward to hearing from you.

 

Best regards.

 

If you are not moving forward, you are really moving backward.

Y Udaya Chandar

 

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News Network
March 28,2020

Berlin, Mar 28: The number of confirmed coronavirus infections worldwide topped 600,000 on Saturday as new cases stacked up quickly in Europe and the United States and officials dug in for a long fight against the pandemic.

The latest landmark came only two days after the world passed half a million infections, according to a tally by John Hopkins University, showing that much work remains to be done to slow the spread of the virus. It showed more than 602,000 cases and a total of over 27,000 deaths.

While the U.S. now leads the world in reported infections — with more than 104,000 cases — five countries exceed its roughly 1,700 deaths: Italy, Spain, China, Iran and France.

“We cannot completely prevent infections at this stage, but we can and must in the immediate future achieve fewer new infections per day, a slower spread,” German Chancellor Angela Merkel, who is in quarantine at home after her doctor tested positive for the virus, told her compatriots in an audio message. “That will decide whether our health system can stand up to the virus.”

The virus already has put health systems in Italy, Spain and France under extreme strain. Lockdowns of varying severity have been introduced across Europe. Merkel's chief of staff, Helge Braun, said that Germany — where authorities closed nonessential shops and banned gatherings of more than two in public — won't relax its restrictions before April 20.

As the epicenter has shifted westward, the situation has calmed in China, where some restrictions on people's lives have now been lifted. Six subway lines restored limited service in Wuhan, where the virus first emerged in December, after the city had its official coronavirus risk evaluation downgraded from high to medium on Friday. Five districts of the city of 11 million people had other restrictions on travel loosened after their risk factor was downgraded to low.

For most people, the coronavirus causes mild or moderate symptoms, such as fever and cough that clear up in two to three weeks. But for others, especially older adults and people with existing health problems, the virus can cause more severe illness, including pneumonia, and lead to death.

More than 130,000 people have recovered, according to Johns Hopkins' tally.

In one way or another, the effects of the COVID-19 outbreak have been felt by the powerful and the poor alike.

On Friday, British Prime Minister Boris Johnson became the first leader of a major country to test positive for the virus. He said he would continue to work from self-quarantine.

Countries are still scrambling bring home some citizens stranded abroad by border closures and a near-shutdown of flights. On Saturday, 174 foreign tourists and four Nepali nationals on the foothills of Mount Everest were flown out days after being stranded on the only airstrip serving the world's highest mountain.

In neighboring India, authorities sent a fleet of buses to the outskirts of the capital to meet an exodus of migrant workers desperately trying to reach their home villages during the world's largest lockdown.

Thousands of people, mostly young male day laborers but also families, had fled their New Delhi homes after Prime Minister Narendra Modi announced a 21-day lockdown that began on Wednesday and effectively put millions of Indians who live off daily earnings out of work.

In a possibly hopeful sign, the U.S. Food and Drug Administration cleared a new rapid test from Abbott Laboratories, which the company says can detect the coronavirus in about 5 minutes. Medical device maker Abbott announced the emergency clearance of its cartridge-based test Friday night, saying the test delivers a negative result in 13 minutes when the virus is not detected.

While New York remained the worst-hit city in the U.S., Americans braced for worsening conditions elsewhere, with worrisome infection numbers being reported in New Orleans, Chicago and Detroit.

New Orleans’ sprawling Ernest N. Morial Convention Center, along the Mississippi River, was being converted into a massive hospital as officials prepared for thousands more patients than they could accommodate.

In New York, where there are more than 44,000 cases statewide, the number of people hospitalized with COVID-19 passed 6,000 on Friday, double what it had been three days earlier.

Gov. Andrew Cuomo called for 4,000 more temporary beds across New York City, where the Jacob K. Javits Convention Center has already been converted into a hospital.

The struggle to defeat the virus will take “weeks and weeks and weeks,” Cuomo told members of the National Guard working at the Javits Center.

President Donald Trump invoked the Defense Production Act on Friday, ordering General Motors to begin manufacturing ventilators. Trump had previously rejected Cuomo's pleas for tens of thousands more of the machines and the governor's calls to implement the Korean War-era production law.

Trump signed a $2.2 trillion stimulus package, after the House approved the sweeping measure by voice vote. Lawmakers in both parties lined up behind the law to send checks to millions of Americans, boost unemployment benefits, help businesses and toss a life preserver to an overwhelmed health care system.

Dr. John Brooks of the U.S. Centers for Disease Control and Prevention warned Americans remained “in the acceleration phase” of the pandemic and that all corners of the country were at risk.

"There is no geographic part of the United States that is spared from this," he said.

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