Mangaluru: Youth hacked to death at Katipalla in broad daylight

Mangaluru, Mar 30: Indira Canteens and Kadiri Manjunatha Temple here have started distributing food packets to the poor, stranded labours, destitute and needy in the wake of the COVID-19 lockdown.

''We have prepared over 2,000 food packets in the morning. The same number will be prepared in the afternoon and night for distribution," said Prabhakar Shetty from Indira canteen at Urwastore in Mangaluru on Monday.

"The MCC teams come and collect food for distribution among the poor, beggars and destitute," he added.

New Delhi, Jan 9: Crime in India has increased by 1.3 per cent in 2018 compared to 2017 with the registration of over 50 lakh cognisable crimes, reveals 2018 edition of 'Crime in India' statistics released this week by the National Crime Records Bureau (NCRB).

As per the NCRB, which works under the Ministry of Home Affairs, a total of 50.74 lakh crimes, including 31.32 lakh under the Indian Penal Code (IPC) and 19.41 under the Special Local Laws (SLL) was registered in 2018.

The report says that there was an overall rise of 1.3 per cent in the registration of cases in 2017, but crime rate per lakh population was down to 383.5 in 2018 from 388.6 in 2017.

A total of 1.05 lakh cases of kidnapping and abduction across the country was registered in 2018, showing an increase of 10.3 per cent over 95,893 such cases in 2017, the latest NCRB report said.

A total of 29,017 murders were reported in 2018, up by 1.3 per cent over 2017. Of which, disputes were reported as the motive of the highest number of murder cases (9,623) followed by personal vendetta and enmity (3,875) and gain (2,995).

Accidental deaths have also seen a rise to 4,11,824 in 2018 from 3,96,584 in 2017 -- a rise to 31.1 per cent from 30.3 per cent in 2017.

The NCRB report 'Crime in India-2018' said in its disclaimer section that clarifications on data were pending from West Bengal, Arunachal, Meghalaya, Sikkim and Kolkata. Hence, the data from these states and city may be treated as provisional.

No let up in road accident deaths in 2018: NCRB

There were 1,35,051 incidences of deaths due to negligence relating to road accidents in 2018, according to the latest NCRB report on "Crime in India -2018".

When compared to the previous two years, the statistics show that there has been no significant change in the overall situation.

In 2017 there were 1,34,803 incidences reported from across the country, while in 2016 it was 1,35,656.

Incidents of 'Hit and run' accident cases have climbed up marginally over the last year, if the latest figures are any indication. In 2018, the 'hit and run' cases reported were 47,028. In 2017, the cases registered under this category were 43,727.

The data collection process for NCRB report on "Crime in India - 2018" including clarifications from the states/UTs/central agencies started in July, 2019 and continued till December, 2019.

People involved in farming sector, including 5,763 farmers or cultivators, committed suicide during 2018, the report reveals.

The annual data was released around three months after the government released the National Crime Records Bureau (NCRB) report on "Crime in India 2017".

As per the latest data, of the 10,349 persons who committed suicide in 2018, 4,586 were agricultural labourers.

The number of suicides in farming sector in 2018 accounts for 7.7 per cent of the total suicide victims (1,34,516) in the country, the NCRB data said.

Suicides in India in 2018 rose to 1,34,516 from 1,29,887 in 2017. Rate of suicides is also up from 9.9 in 2017 to 10.2 in 2018.

In 2017, a total of 10,655 farmer suicides were reported.

West Bengal, Bihar, Odisha, Uttarakhand, Meghalaya, Goa, Chandigarh, Daman and Diu, Delhi, Lakshadweep and Puducherry reported zero suicides of farmers or cultivators and agricultural labourers during 2018, said the report.

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer.