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Bengaluru, Jun 19: The Karnataka government has been advised by its Educational Advisor to cancel holidays observed in educational institutions on the occasion of various Jayantis (birth annivesaries).

Advisor to Karnataka government on Education, Professor MR Doreswamy, has recommended cancellation of holidays on Jayanti and celebrate the day with more meaningful programmes remembering the great personalities.

The state government has declared public holidays on Valmiki Jayanti, Basava Jayanti, Kanaka Jayanti, Mahavir Jayanti, Ambedkar Jayanti and Gandhi Jayanti.

On Thursday, Doreswamy submitted a report containing seven key suggestions including cancelling holidays, to Deputy Chief Minister CN Aswath Narayan, who holds higher education portfolio.

Doreswamy in his report suggested to hold thematic workshops, lectures, conferences and other such activities to celebrate the life and works of the great personalities, instead of declaring holidays.

"It would not only educate our youth about the significance of the great personalities to our culture and society and also reinvents the tradition of paying tributes to their contributions to our civil society,'' he said.

Dr Narayan said that the decision on cancelling holidays on Jayanti's has to be taken by Chief Minister BS Yediyurappa.

Moreover, to bring education back on track during the present COVID-19 pandemic situation, Doreswamy made a few suggestions to complete exams of final semester engineering and graduate students. He also said that it was a challenge for the education sector to overcome the pandemic crisis and structure the next academic year 2021-22.

He also advised implementation of a mentoring system in all higher education institutions in Karnataka and empowering specially-abled students.

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Bengaluru, May 26: Unknown miscreants have set ablaze 30-40 migrant labourers hutments in Bengaluru east, prompting police to take suo motu cognizance, an official said on Tuesday.

"As many as 30-40 migrant labourers' hutments have been set ablaze by unknown miscreants at Kacharakanahallin in KG Halli, we have taken suo motu cognizance of the crime," said a police official to media.

Police are investigating the arson invoking IPC Sections 143, 147, 188, 436, 123, 504, 506 and others.

"There was no loss of life in the arson as the migrant labourers were away at their hometowns because of COVID lockdown," said the official.

The labourers came from different parts of Karnataka to eke out a living and were living in those huts near the Rama Temple in KG Halli.