Nagara Panchami: Hindus in Mangaluru express reverence towards Serpent

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

New Delhi, Jul 16: India’s Covid-19 tally on Thursday jumped to 968,876 after the country reported highest-ever single-day spike in coronavirus cases registering 32,695 new infections in the last 24 hours. According to the government data, India’s Covid-19 death toll stands at 24,915 after 606 fresh fatalities were reported in the last 24 hours.

The number of recovered patients in India stands at 612,814. On Wednesday, the government said that a record 20,572 patients recuperated from Covid-19 disease in the last 24 hours (between Tuesday and Wednesday), taking the country’s recovery rate to 63.24 percent.

While the Covid-19 tally runs in lakhs in states like Maharashtra, Delhi and Tamil Nadu, other states have been reporting a surge in coronavirus infections. Karnataka has reported over 47,000 coronavirus cases till date but its active cases are more that of Delhi. It has overtaken Gujarat as the fourth worst-hit state in the country. Gujarat’s Covid-19 tally stands at 44,552.

Here’s taking a look at the Covid-19 situation across worst-affected states:

Maharashtra

The state Covid-19 tally jumped to 275,640 on Thursday. As many as 152,613 people have recovered from coronavirus in Maharashtra while 10,928 have died.

Tamil Nadu

With 151,820 coronavirus cases, Tamil Nadu is the state with second-highest coronavirus cases in the country and has witnessed 2,167 coronavirus fatalities. The number of patients who have recovered from coronavirus in the state stands at 102,310.

Delhi

The national capital is the third worst-hit in India with coronavirus cases jumping to 116,993 on Thursday. As many as 95,699 patients have recovered from Covid-19 in the national capital while 3,487 have succumbed to the infection.

Karnataka

The South Indian state has witnessed 47,253 coronavirus cases till date and is now the fourth worst-affected in the country. While 928 have lost their lives to the deadly contagion in the state. Nearly 18,466 patients have recovered from the disease in Karnataka.

Gujarat

Gujarat has seen Covid-19 cases reach 44,552 on Thursday. The state has seen 31,286 people recover from coronavirus while 2,079 people have died.

Uttar Pradesh

The Covid-19 tally in Uttar Pradesh has jumped to 41,383 while the number of recoveries has touched 25,743. The state’s death toll has crossed 1,000.

Telangana

The state’s Covid-19 tally stands at 39,342 coronavirus cases. While 25,999 people have recovered from the disease, the Covid-19 death toll has jumped to 386 in the state.

Andhra Pradesh

The state has reported 35,451 Covid-19 patients till date. While 18,378 people have recovered from the virus across the state, the death toll stands at 452.

West Bengal

As many as 34,427 people have contracted Covid-19 in West Bengal till date. The state has seen 20,680 recover from coronavirus while 1,000 people have been killed.

Rajasthan

The state has reported 26,437 Covid-19 cases till date. Covid-19 death toll in Rajasthan stands at 530 while 19,502 patients have recovered.

Mysuru, Feb 7: Former chief minister and Janata Dal (Secular) leader HD Kumaraswamy on Thursday said that Chief Minister BS Yediyurappa-led government is not stable and it can fall at any moment.

"Karnataka Government is not a stable one. With the developments taking place, it can fall at any moment," Kumaraswamy told reporters when asked to comment on the Karnataka Cabinet expansion.

Earlier in the day, 10 MLAs including Ramesh Jarkiholi, Anand Singh, K Sudhakar and BA Basavaraja took oath as Cabinet Ministers at Raj Bhawan in Bengaluru.