New smartphone device to test male fertility developed

March 23, 2017

Boston, Mar 23: Scientists have developed a new smartphone-based device to measure semen quality, an advance that may prove to be a boon in countries lacking access to fertility tests.

fertilityResearchers, including those from Massachusetts General Hospital (MGH) in the US, have built an analyser consisting of an optical attachment that can connect to a smartphone and a disposable device onto which a semen sample can be loaded.

The new test utilises the advancements in consumer electronics and microfabrication. A disposable microchip with a capillary tip and a rubber bulb is used for simple, power-free semen sample handling.

Scientists also designed a user-friendly smartphone application that guides the user through each step of testing, and a miniaturised weight scale that wirelessly connects to smartphones to measure total sperm count.

Researchers collected and studied about 350 clinical semen specimens at the MGH Fertility Centre to evaluate the test.

Overall, the smart phone-based device was able to detect abnormal semen samples based on World Health Organisation (WHO) thresholds for sperm concentration and motility with an accuracy of 98 per cent.

The team also evaluated how well both trained and untrained users performed the test using the smartphone-based device.

"We wanted to come up with a solution to make male infertility testing as simple and affordable as home pregnancy tests," said Hadi Shafiee of Brigham and Women's Hospital in the US.

"Current clinical tests are lab-based, time-consuming, and subjective. This test is low-cost, quantitative, highly accurate, and can analyse a video of an undiluted, unwashed semen sample in less than five seconds," Shafiee added.

The study was published in the journal Science Translational Medicine.

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News Network
May 30,2020

May 30: Patients undergoing surgery after contracting the novel coronavirus are at an increased risk of postoperative death, according to a new study published in The Lancet journal which may lead to better treatment guidelines for COVID-19.

In the study, the scientists, including those from the University of Birmingham in the UK, examined data from 1,128 patients from 235 hospitals from a total of 24 countries.

Among COVID-19 patients who underwent surgery, they said the death rates approach those of the sickest patients admitted to intensive care after contracting the virus.

The scientists noted that SARS-CoV-2 infected patients who undergo surgery, experience substantially worse postoperative outcomes than would be expected for similar patients who do not have the infection.

According to the study, the 30-day mortality among these patients was nearly 24 per cent.

The researchers noted that mortality was disproportionately high across all subgroups, including those who underwent elective surgery (18.9 per cent), and emergency surgery (25.6 per cent).

Those who underwent minor surgery, such as appendicectomy or hernia repair (16.3 per cent), and major surgery such as hip surgery or for colon cancer also had higher mortality rates (26.9 per cent), the study said.

According to the study, the mortality rates were higher in men versus women, and in patients aged 70 years or over versus those aged under 70 years.

The scientists said in addition to age and sex, risk factors for postoperative death also included having severe pre-existing medical problems, undergoing cancer surgery, undergoing major procedures, and undergoing emergency surgery.

"We would normally expect mortality for patients having minor or elective surgery to be under 1 per cent, but our study suggests that in SARS-CoV-2 patients these mortality rates are much higher in both minor surgery (16.3%) and elective surgery (18.9%)," said study co-author Aneel Bhangu from the University of Birmingham.

Bhangu said these mortality rates are greater than those reported for even the highest-risk patients before the pandemic.

Citing an example from the 2019 UK National Emergency Laparotomy Audit report, he said the 30-day mortality was 16.9 per cent in the highest-risk patients.

Based on an earlier study across 58 countries, Bhangu said the 30-day mortality was 14.9 per cent in patients undergoing high-risk emergency surgery.

"We recommend that thresholds for surgery during the SARS-CoV-2 pandemic should be raised compared to normal practice," he said.

"For example, men aged 70 years and over undergoing emergency surgery are at particularly high risk of mortality, so these patients may benefit from their procedures being postponed," Bhangu added.

The study also noted that patients undergoing surgery are a vulnerable group at risk of SARS-CoV-2 exposure in hospital.

It noted that the patients may also be particularly susceptible to subsequent pulmonary complications, due to inflammatory and immunosuppressive responses to surgery and mechanical ventilation.

The scientists found that overall in the 30 days following surgery 51 per cent of patients developed a pneumonia, acute respiratory distress syndrome, or required unexpected ventilation.

Nearly 82 per cent of the patients who died had experienced pulmonary complications, the researchers said.

"Worldwide an estimated 28.4 million elective operations were cancelled due to disruption caused by COVID-19," said co-author Dmitri Nepogodiev from the University of Birmingham.

"Our data suggests that it was the right decision to postpone operations at a time when patients were at risk of being infected with SARS-CoV-2 in hospital," Nepogodiev said.

According to the researchers, there's now an urgent need for investment by governments and health providers in to measures which ensure that as surgery restarts patient safety is prioritised.

They said this includes the provision of adequate personal protective equipment (PPE), establishment of pathways for rapid preoperative SARS-CoV-2 testing, and consideration of the role of dedicated 'cold' surgical centres.

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Agencies
March 16,2020

While Google is still working on a coronavirus screening and tracking website, Microsoft Bing team has already launched a web portal for tracking COVID-19 infections worldwide.

The website, accessible at bing.com/covid, provides up-to-date infection statistics for each country.

The COVID-19 Tracker currently lists 168,835 as total confirmed cases, 84,558 active cases, 77,761 recovered cases and 6,516 deaths.

There are at least 3,244 confirmed cases of novel coronavirus in the US and at least 61 deaths.

"Lots of Bing folks worked (from home) this past week to create a mapping and authoritative news resource for COVID19 info," Michael Schechter, General Manager for Bing Growth and Distribution at Microsoft, was quoted as saying in a ZDNet report on Sunday.

An interactive map allows site visitors to click on the country to see the specific number of cases and related articles from a variety of publishers.

Data is being aggregated from sources like the World Health Organization (WHO), the US Centers for Disease Control and Prevention (CDC), and the European Centre for Disease Prevention and Control (ECDC).

Microsoft announced the website two days after US President Donald Trump said Google has begun working on COVID-19-related portal for US citizens.

Google's website is being built by Verily, a subsidiary of Alphabet focused on healthcare services.

"More than 1,700 engineers are currently working on the site", Trump said during a press briefing last week.

The tool will triage people who are concerned about their COVID-19 risk into testing sites based on guidance from public health officials and test availability.

Initially, there was some confusion on Google's coronavirus portal but the company later announced that it is "partnering with the US Government in developing a nationwide website that includes information about COVID-19 symptoms, risk, and testing information."

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Agencies
February 23,2020

Google has indexed invite links to private WhatsApp group chats, meaning anyone can join various private chat groups (including several porn-sharing groups) with a simple search.

According to a report in Motherboard, invitations to WhatsApp group chats were being indexed by Google.

The team found private groups using specific Google searches and even joined a group intended for NGOs accredited by the UN and had access to all the participants and their phone numbers.

Journalist Jordan Wildon said on Twitter that he discovered that WhatsApp's "Invite to Group Link" feature lets Google index groups, making them available across the internet since the links are being shared outside of WhatsApp's secure private messaging service.

"Your WhatsApp groups may not be as secure as you think they are," Wildon tweeted on Friday, adding that using particular Google searches, people can discover links to the chats.

According to app reverse-engineer Jane Wong, Google has around 470,000 results for a simple search of "chat.whatsapp.com", part of the URL that makes up invites to WhatsApp groups.

WhatsApp spokesperson Alison Bonny said: "Like all content that is shared in searchable public channels, invite links that are posted publicly on the internet can be found by other WhatsApp users."

"The links that users wish to share privately with people they know and trust should not be posted on a publicly accessible website," Bonny told The Verge.

Danny Sullivan, Google's public search liaison, tweeted: "Search engines like Google & others list pages from the open web. That's what's happening here. It's no different than any case where a site allows URLs to be publicly listed. We do offer tools allowing sites to block content being listed in our results."

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