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May 12: Children suffering from non-respiratory disease symptoms like diarrhea and fever, or those with a history of exposure to the novel coronavirus, should be suspected of having COVID-19, a new study says.

According to the research, published in the journal Frontiers in Pediatrics, gastrointestinal symptoms first suffered by some children hints at potential infection with SARS-CoV-2 through the digestive tract.

"This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children," the scientists from Tongji Hospital in China wrote in the study.

They explained that the gastrointestinal symptoms could be arising since the type of receptors in lung cells targeted by the virus can also be found in the intestines.

Most children are only mildly affected by COVID-19, and the few severe cases often have underlying health issues, the researchers said.

"It is easy to miss its diagnosis in the early stage, when a child has non-respiratory symptoms, or suffers from another illness," said study co-author Wenbin Li, who works at the Department of Pediatrics, Tongji Hospital.

"Based on our experience of dealing with COVID-19, in regions where this virus is epidemic, children suffering from digestive tract symptoms, especially with fever and/or a history of exposure to this disease, should be suspected of being infected with this virus," Li said.

In the study, the scientists described the clinical features of children admitted to hospital with non-respiratory symptoms, who were subsequently diagnosed with pneumonia and COVID-19.

"These children were seeking medical advice in the emergency department for unrelated problems, for example, one had a kidney stone, another a head trauma," Li said.

The study noted that all the children had pneumonia, which was confirmed by chest X-ray scan before or soon after admission.

These children were then confirmed to have COVID-19.

While their COVID-19 symptoms were initially mild or relatively hidden before their hospital admission, four out of the five cases had digestive tract symptoms as the first manifestation of this disease, the researchers said.

Li hopes that doctors will use the findings to quickly diagnose and isolate patients with similar symptoms, which may aid early treatment and reduce transmission.

According to the researchers, the children's gastrointestinal symptoms, which have also been recorded in adult patients, could be an additional route of infection.

"The gastrointestinal symptoms experienced by these children may be related to the distribution of receptors and the transmission pathway associated with COVID-19 infection in humans," Li explained.

Since the virus infects people via the ACE2 receptor, which can be found in certain cells in the lungs as well as the intestines, COVID-19 might infect patients not only through the respiratory tract in the form of air droplets, but also through the digestive tract by contact or fecal-oral transmission, the study noted.

While COVID-19 tests can occasionally produce false positive readings, Li said all the five children assessed in the study were infected with the disease.

However, he cautioned that more research is needed to confirm their findings.

"We report five cases of COVID-19 in children showing non-respiratory symptoms as the first manifestation after admission to hospital. The incidence and clinical features of similar cases needs further study in more patients," he said.

Bengaluru, May 30: Karnataka Chief Minister BS Yediyurappa has announced that on May 31 (Sunday) there will not be a total lockdown and all activities will be permitted and continue like the rest of the week.

The decision was taken in view of demands from citizens and “keeping their interests in mind,” said a statement from the Chief Minister’s Office (CMO).

This means that public transport services - buses, autos and cabs - shops, commercial establishments and others will be open on May 31.

Under a Lockdown 4.0, Karnataka had decided to throw open public transport, except metro, shops and commercial establishments, except Metro, on all six days between 7 am and 7 pm. However, May 24 and May 31 - Sundays - were exempted from the relaxation and a curfew was to be imposed throughout the day.

The Lockdown 4.0 ends May 31 and the government's decision to keep Sunday free comes ahead of the Lockdown 5.0 that the Centre is expected to announce soon.

Bengaluru, Apr 16: With two more people testing positive for COVID-19 in Karnataka, the state's corona cases count has reached 279, including 80 discharged and 12 deaths, said the government on Wednesday.

A total of 19 corona cases were confirmed in the state on Wednesday. 17 cases were reported earlier in the day, of which 15 are male patients and two are female. Of the 17 cases, nine are workers of a pharmaceutical company in Mysuru, the government stated.

Meanwhile, a 65-year-old from Chikkaballapur, who had tested positive for COVID-19, lost his life this afternoon.

"He was referred to a Bengaluru hospital with complaints of H1N1 positive, chronic obstructive pulmonary disease with obstructive sleep apnea and a past history of diabetes and hypertension," the government said.