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Idukki, Aug 8: Nine more bodies have been recovered from the landslide ravaged Pettimudi near Munnar in Idukki on Saturday. With this the death toll in the tragedy reached 26. Around 40 are feared to be still trapped under the debris or washed away.

The rescue operation by NDRF and Fire and Rescue Services that was stopped by Friday evening due to poor light and bad weather resumed by Saturday morning.

Horrifying scene prevailed in the area as relatives of the missing people screamed around in search of their beloved ones. As it is nearly 48 hours since the incident happened, the chances of recovering missing persons alive from the debris is becoming bleak. Three of the bodies recovered on Saturday could not be identified till evening.

Kerala Revenue Minster E Chandrasekharan, who visited the area on Saturday, said that search operation would be carried out until all the missing are recovered.

It was by around 11.30 pm on Thursday that landslide had hit the Nayamakkad estate of Kannan Devan Hills and Plantations. Settlement clusters of plantation workers where 83 persons were staying were reduced to debris as the huge rocks came bulldozing. Five of the residents were reported to be not in the spot while the mishap occured.

Meanwhile, heavy rains led to floods at many parts of the state. Red alert has been issued at Idukki, Malappuram and Wayanad districts for Sunday also. A total of 11,446 persons of 3,530 families were shifted to relief camps across the state, of which major chunk is at Wayanad.

Chief Minister Pinarayi Vijayan said that water level at most dams is increasing swiftly.

The Drugs Controller General of India (DCGI) has given nod to the Serum Institute of India (SII) for conducting phase 2 and 3 human clinical trials of the Oxford University developed Covid-19 vaccine candidate in the country.

Government officials said that the approval for conducting phase 2 and 3 clinical trials by the SII was granted by DCGI Dr V G Somani late Sunday night after a thorough evaluation based on the recommendations of the Subject Expert Committee (SEC) on Covid-19.

"The firm has to submit safety data, evaluated by the Data Safety Monitoring Board (DSMB), to the CDSCO before proceeding to phase 3 clinical trials," a senior official said.

"As per the study design, each subject will be administered two doses four weeks apart (first dose on day one and second dose on day 29) following which the safety and immunogenicity will be assessed at predefined intervals," the official said.

As a rapid regulatory response, the expert panel at the Central Drugs Standard Control Organisation (CDSCO) on Friday, after a detailed deliberation and considering the data generated on the vaccine candidate in phase 1 and 2 of the Oxford University trial, had recommended granting permission for phase 2 and 3 clinical trials of the potential vaccine, 'Covishield', on healthy adults in India,  the officials said.

Currently, phase 2 and 3 clinical trials of the Oxford vaccine candidate is going on in the United Kingdom, phase 3 clinical trial in Brazil and phase 1 and 2 clinical trials in South Africa.

The officials said that the SII had submitted a revised proposal on Wednesday after the SEC on July 28, following deliberation over its application, had asked it to revise its protocol for the phase 2 and 3 clinical trials besides seeking some additional information.

The panel had also recommended that the clinical trial sites which have been proposed for the study be distributed across India.

According to the revised proposal by the SII, 1,600 people aged above 18 years will participate in the trials across 17 selected sites, including AIIMS-Delhi, B J Medical College in Pune, Rajendra Memorial Research Institute of Medical Sciences (RMRIMS) in Patna, Post Graduate Institute of Medical Education and Research in Chandigarh, AIIMS-Jodhpur, Nehru Hospital in Gorakhpur, Andhra Medical College in Visakhapatnam and JSS Academy of Higher Education and Research in Mysore.

"According to the application, it would conduct an observer-blind, randomised controlled study to determine the safety and immunogenicity of 'Covishield' on healthy Indian adults," the official said.

The SII, which has partnered with AstraZeneca, for manufacturing the Oxford vaccine candidate for Covid-19 had submitted its first application to the DCGI on July 25 seeking permission for conducting the phase 2 and 3 trials of the potential vaccine. 

Initial results of the first two-phases of trials of the vaccine conducted in five trial sites in the UK showed that it has an acceptable safety profile and homologous boosting increased antibody response, sources had said.

To introduce the vaccine, SII, the world's largest vaccine maker by number of doses produced and sold, has signed an agreement to manufacture the potential vaccine developed by the Jenner Institute (Oxford University) in collaboration with British-Swedish pharma company AstraZeneca.