Rambhapuri seers warns of waging religious war

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Kundapur, Mar 2: A 43-year-old man was arrested by the local police in Udupi district after he allegedly raised pro-Pakistan at Mini Vidhana Soudha in Kundapur today morning.

The man has been identified as Raghavendra Ganiga (43), a resident of Kody in Kundapur. He was working as a Hindi teacher in a private school in the town a few years ago.

According to sources, Ganiga arrived at the Mini Vidhana Soudha at around 10 am and scaled the steps to the building raising 'Pakistan Zindabad' slogans repeatedly.

He continued to raise slogans on the corridor and after entering a hall.  A few people recorded this drama on their mobile phones and informed the police.

Later, Kundapur tahisldar filed a written complaint against with the local police, who took Ganiga into custody.

According to police, Ganiga was under depression after his wife deserted him and left him with their only child.

Mangaluru, Jan 3: S Cube Art Gallery has successfully concluded its prestigious assignment from Airports Authority of India (AAI) to beautify Mangaluru Airport with artistic works. AAI had invited tenders for various jobs to be executed in the airport premises. S Cube Art Gallery had made a competitive bid which was subsequently followed up with presentation before selection panel and award of contract. S Cube Art Gallery bagged the contract for six works in two sectors out of the total four sectors for which the tender had been called.

The themes presented by S Cube Art Gallery showcase the Tulu culture and heritage of the people of Coastal Karnataka. The six themes selected are:

1. ‘Human Hand Flying Paper Plane’ – fibre glass and steel sculpture work installed in the circle in the outer precincts of the airport. This is a larger than life sculpture signifying the dreams and aspirations of the air travelers. Artist: Harish Kodialbail, Mangalore

2. ‘Kambala’ – fibre glass sculpture installed at the exit area of the airport. This sculpture is meant to introduce ‘Kambala’, the iconic folk sport of the region to the visitors and tourists. Artist: Harish Kodialbail, Mangalore

3. ‘Fisherman with Boat’ - fibre glass and steel sculpture installed at the entrance to departures lounge of the airport. It symbolizes the fishing culture of the coastal region depicting the soaring aspirations, life of courage and adventure as well as the daily struggles of the fisher folk. Artist: Harish Kodialbail, Mangalore

4. ‘Tiger Dance’ - fibre glass and steel sculpture installed at the arrivals lounge of the airport. This work depicts the world famous ‘Mangalore Pilivesha’ showing tiger dancers in various typical postures to the visiting tourists. Artist: Harish Kodialbail, Mangalore

5. ‘Folk Art Forms’ – six individual terracotta sculptures with Tulunadu cultural themes installed alongside the domestic and international corridors of the airport. Artist: Venki Palimaru, Udupi

6. ‘Jain Miniature Paintings’ – Jain miniature paintings (18x6 feet) – Two works of acrylic on canvas displayed on the wall on either sides of the exit area. The work was conceived after referring to authentic traditional Jain paintings in Moodbidri Jain Mutt and Shravanabelagola Mutt. Artist: Reshma S. Shetty, Mangalore

The total value of the contract was Rs. 56 lakhs. The work was completed over a period of six months and concluded in the month of July, 2019.  S Cube Art Gallery is grateful to the Airports Authority of India for giving the opportunity to participate in this project and showcase the artistic talents of the region.