Saina Nehwal Joins BJP, says wish to “serve” country like Modi

Beijing/Zurich, Mar 4: China has approved the use of Swiss drugmaker Roche's anti-inflammation drug Actemra for patients who develop severe complications from the coronavirus as it urgently hunts for new ways to combat the deadly infection that is spreading worldwide.

China is hoping that some older drugs could stop severe cytokine release syndrome (CRS), or cytokine storms, an overreaction of the immune system which is considered a major factor behind catastrophic organ failure and death in some coronavirus patients.

Actemra, a biologic drug approved in 2010 in the United States for rheumatoid arthritis (RA), inhibits high Interleukin 6 (IL-6) protein levels that drive some inflammatory diseases.

China's National Health Commission said in treatment guidelines published online on Wednesday that Actemra can now be used to treat coronavirus patients with serious lung damage and high IL-6 levels.

Separately, researchers in the country are testing Actemra, known generically as tocilizumab, in a clinical trial expected to include 188 coronavirus patients and running until May 10.

Roche, which donated 14 million yuan ($2.02 million) worth of Actemra during February, said the trial was initiated independently by a third party with the aim of exploring the efficacy and safety of the drug in coronavirus patients with CRS.

It added that there was currently no published clinical trial data on the drug's safety or efficacy against the virus.

More than 3,000 people have died and 93,000 have been infected by the novel coronavirus thought to have originated in Wuhan, China, before spreading to around 90 countries including the United States, Italy, Switzerland, France and Germany.

The Swiss company, for which China is its No. 2 market behind the United States, also makes diagnostic gear to detect the coronavirus.

Since Actemra's approval a decade ago, it has become a go-to drug against other inflammatory conditions, including cytokine storms in cancer patients receiving cell therapies from Novartis and Gilead Sciences.

In 2012 it helped save the life of a young U.S. girl, the first child to be treated for leukaemia with Novatis' Kymriah, from a post-treatment rush of IL-6.

Priced at between $20-30,000 annually for RA according to SSR Health, Roche's medicine is also used for rare juvenile arthritis and giant cell arteritis, or inflammation of the blood vessels.

New Delhi, Jun 24: Former England skipper Michael Vaughan has slammed UK Prime Minister Boris Johnson for not allowing recreational cricket to resume.

UK Prime Minister Boris Johnson had described the cricket ball as a 'natural vector of disease' and ruled out recreational cricket's return in the country.

Hearing Johnson's argument, Vaughan tweeted: "Hand sanitiser in every players pocket. Use every time you touch the ball ... SIMPLE ... Recreational Cricket should just play from July 4th ... utter nonsense it's not being allowed back ... #Cricket."

Johnson was responding to a question from Conservative MP Greg Clark in the House of Commons, and it was then that Johnson said that it is too soon to lift current restrictions to allow the return of recreational cricket.

"The problem with cricket as everybody understands is that the ball is a natural vector of disease, potentially at any rate. We've been around it many times with our scientific friends," ESPNCricinfo had quoted Johnson as saying.

"At the moment, we're still working on ways to make cricket more COVID-secure but we can't change the guidance yet," he added.

Johnson had announced various relaxations on Tuesday, but the return of recreational cricket was not a part of them.

However, this statement given by Johnson will have no impact on the Test series between England and West Indies, scheduled to begin from July 8.

However, the England and Wales Cricket Board (ECB) has said that it is looking to resume recreational cricket in the country around July 4.

The board has also said that cricket is a low-risk sport as it is a non-contact sport.

"We believe that cricket is a non-contact sport, with very low risks of exposure, and that it can be played as safely as many other activities being currently permitted," the ECB said in an official statement.

"It is our strong desire to work with Government to see the return of recreational cricket on or around 4th July, as they continue to lift other restrictions more broadly across society," it added.

All international cricket has also been suspended since March due to the coronavirus pandemic.

However, it is set to resume to from July 8 as England and West Indies will lock horns in the three-Test series.