Scientists discover mechanism that may prevent death of cells

May 30: Patients undergoing surgery after contracting the novel coronavirus are at an increased risk of postoperative death, according to a new study published in The Lancet journal which may lead to better treatment guidelines for COVID-19.

In the study, the scientists, including those from the University of Birmingham in the UK, examined data from 1,128 patients from 235 hospitals from a total of 24 countries.

Among COVID-19 patients who underwent surgery, they said the death rates approach those of the sickest patients admitted to intensive care after contracting the virus.

The scientists noted that SARS-CoV-2 infected patients who undergo surgery, experience substantially worse postoperative outcomes than would be expected for similar patients who do not have the infection.

According to the study, the 30-day mortality among these patients was nearly 24 per cent.

The researchers noted that mortality was disproportionately high across all subgroups, including those who underwent elective surgery (18.9 per cent), and emergency surgery (25.6 per cent).

Those who underwent minor surgery, such as appendicectomy or hernia repair (16.3 per cent), and major surgery such as hip surgery or for colon cancer also had higher mortality rates (26.9 per cent), the study said.

According to the study, the mortality rates were higher in men versus women, and in patients aged 70 years or over versus those aged under 70 years.

The scientists said in addition to age and sex, risk factors for postoperative death also included having severe pre-existing medical problems, undergoing cancer surgery, undergoing major procedures, and undergoing emergency surgery.

"We would normally expect mortality for patients having minor or elective surgery to be under 1 per cent, but our study suggests that in SARS-CoV-2 patients these mortality rates are much higher in both minor surgery (16.3%) and elective surgery (18.9%)," said study co-author Aneel Bhangu from the University of Birmingham.

Bhangu said these mortality rates are greater than those reported for even the highest-risk patients before the pandemic.

Citing an example from the 2019 UK National Emergency Laparotomy Audit report, he said the 30-day mortality was 16.9 per cent in the highest-risk patients.

Based on an earlier study across 58 countries, Bhangu said the 30-day mortality was 14.9 per cent in patients undergoing high-risk emergency surgery.

"We recommend that thresholds for surgery during the SARS-CoV-2 pandemic should be raised compared to normal practice," he said.

"For example, men aged 70 years and over undergoing emergency surgery are at particularly high risk of mortality, so these patients may benefit from their procedures being postponed," Bhangu added.

The study also noted that patients undergoing surgery are a vulnerable group at risk of SARS-CoV-2 exposure in hospital.

It noted that the patients may also be particularly susceptible to subsequent pulmonary complications, due to inflammatory and immunosuppressive responses to surgery and mechanical ventilation.

The scientists found that overall in the 30 days following surgery 51 per cent of patients developed a pneumonia, acute respiratory distress syndrome, or required unexpected ventilation.

Nearly 82 per cent of the patients who died had experienced pulmonary complications, the researchers said.

"Worldwide an estimated 28.4 million elective operations were cancelled due to disruption caused by COVID-19," said co-author Dmitri Nepogodiev from the University of Birmingham.

"Our data suggests that it was the right decision to postpone operations at a time when patients were at risk of being infected with SARS-CoV-2 in hospital," Nepogodiev said.

According to the researchers, there's now an urgent need for investment by governments and health providers in to measures which ensure that as surgery restarts patient safety is prioritised.

They said this includes the provision of adequate personal protective equipment (PPE), establishment of pathways for rapid preoperative SARS-CoV-2 testing, and consideration of the role of dedicated 'cold' surgical centres.

San Francisco, Mar 18: Facebook said a bug in its anti-spam system temporarily blocked the publication of links to news stories about the coronavirus. Guy Rosen, Facebook's vice president of integrity, said on Twitter Tuesday that the company was working on a fix for the problem.

Users complained that links to news stories about school closings and other information related to the virus outbreak were blocked by the company's automated system.

Later on Tuesday, Rosen tweeted that Facebook had restored all the incorrectly deleted posts, which also covered topics beyond the coronavirus.

Rosen said the problems were unrelated to any changes in Facebook's content-moderator workforce. The company reportedly sent its human moderators home this week because of the coronavirus outbreak.

A representative for Facebook did not immediately respond to questions on the status of Facebook's content moderators, many of whom do not work directly for the company and are not always able to work from home.

San Francisco, Feb 5: After a German artist, Simon Weckert, demonstrated how he "hacked" Google Maps with 99 smartphones and a wagon to create "virtual traffic jams" on the streets of Berlin, Google responded to the incident saying it "appreciates" creative use of maps.

Admitting that it has not quite cracked travelling by wagon, the tech giant also hinted that it might use cases like this to improve how its maps work.

"We appreciate seeing creative uses of Google Maps like this as it helps us make maps work better over time," 9to5Google quoted a Google spokesperson as saying.

In a YouTube video, Weckert showed that he put 99 smartphones with Google Maps onto a small wagon cart and then wheeled that cart around various streets in Berlin, including outside the Google office, Android Authority reported on Monday.

The smartphones "apparently fooled Google Maps" into thinking that there was a high concentration of users on those streets.

Because the second-hand phones were in a cart, Maps was further tricked into believing that the traffic was slow-moving.

As a result, the navigation app started showing virtual traffic jams by turning green streets to red in the online navigational tool, showcasing how digital technology can have a real impact on the real world.

"Traffic data in Google Maps is refreshed continuously thanks to information from a variety of sources, including aggregated anonymised data from people who have location services turned on and contributions from the Google Maps community," the Google spokesperson said.

"We've launched the ability to distinguish between cars and motorcycles in several countries including India, Indonesia and Egypt, though we haven't quite cracked travelling by wagon," the statement added. After a German artist, Simon Weckert, demonstrated how he "hacked" Google Maps with 99 smartphones and a wagon to create "virtual traffic jams" on the streets of Berlin, Google responded to the incident saying it "appreciates" creative use of maps.

Admitting that it has not quite cracked travelling by wagon, the tech giant also hinted that it might use cases like this to improve how its maps work.

"We appreciate seeing creative uses of Google Maps like this as it helps us make maps work better over time," 9to5Google quoted a Google spokesperson as saying.

In a YouTube video, Weckert showed that he put 99 smartphones with Google Maps onto a small wagon cart and then wheeled that cart around various streets in Berlin, including outside the Google office, Android Authority reported on Monday.

The smartphones "apparently fooled Google Maps" into thinking that there was a high concentration of users on those streets.

Because the second-hand phones were in a cart, Maps was further tricked into believing that the traffic was slow-moving.

As a result, the navigation app started showing virtual traffic jams by turning green streets to red in the online navigational tool, showcasing how digital technology can have a real impact on the real world.

"Traffic data in Google Maps is refreshed continuously thanks to information from a variety of sources, including aggregated anonymised data from people who have location services turned on and contributions from the Google Maps community," the Google spokesperson said.

"We've launched the ability to distinguish between cars and motorcycles in several countries including India, Indonesia and Egypt, though we haven't quite cracked travelling by wagon," the statement added.