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May 12: Children suffering from non-respiratory disease symptoms like diarrhea and fever, or those with a history of exposure to the novel coronavirus, should be suspected of having COVID-19, a new study says.

According to the research, published in the journal Frontiers in Pediatrics, gastrointestinal symptoms first suffered by some children hints at potential infection with SARS-CoV-2 through the digestive tract.

"This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children," the scientists from Tongji Hospital in China wrote in the study.

They explained that the gastrointestinal symptoms could be arising since the type of receptors in lung cells targeted by the virus can also be found in the intestines.

Most children are only mildly affected by COVID-19, and the few severe cases often have underlying health issues, the researchers said.

"It is easy to miss its diagnosis in the early stage, when a child has non-respiratory symptoms, or suffers from another illness," said study co-author Wenbin Li, who works at the Department of Pediatrics, Tongji Hospital.

"Based on our experience of dealing with COVID-19, in regions where this virus is epidemic, children suffering from digestive tract symptoms, especially with fever and/or a history of exposure to this disease, should be suspected of being infected with this virus," Li said.

In the study, the scientists described the clinical features of children admitted to hospital with non-respiratory symptoms, who were subsequently diagnosed with pneumonia and COVID-19.

"These children were seeking medical advice in the emergency department for unrelated problems, for example, one had a kidney stone, another a head trauma," Li said.

The study noted that all the children had pneumonia, which was confirmed by chest X-ray scan before or soon after admission.

These children were then confirmed to have COVID-19.

While their COVID-19 symptoms were initially mild or relatively hidden before their hospital admission, four out of the five cases had digestive tract symptoms as the first manifestation of this disease, the researchers said.

Li hopes that doctors will use the findings to quickly diagnose and isolate patients with similar symptoms, which may aid early treatment and reduce transmission.

According to the researchers, the children's gastrointestinal symptoms, which have also been recorded in adult patients, could be an additional route of infection.

"The gastrointestinal symptoms experienced by these children may be related to the distribution of receptors and the transmission pathway associated with COVID-19 infection in humans," Li explained.

Since the virus infects people via the ACE2 receptor, which can be found in certain cells in the lungs as well as the intestines, COVID-19 might infect patients not only through the respiratory tract in the form of air droplets, but also through the digestive tract by contact or fecal-oral transmission, the study noted.

While COVID-19 tests can occasionally produce false positive readings, Li said all the five children assessed in the study were infected with the disease.

However, he cautioned that more research is needed to confirm their findings.

"We report five cases of COVID-19 in children showing non-respiratory symptoms as the first manifestation after admission to hospital. The incidence and clinical features of similar cases needs further study in more patients," he said.

Bengaluru, Mar 9: Karnataka government has ordered holidays for children in lower and upper kindergarten classes in Bengaluru, in the wake of coronavirus outbreak and with positive cases being reported from states in its neighbourhood.

"Further to the advice received from the Health Commissioner, holidays have been declared for Lower and Upper Kindergarten classes in Bengaluru North, South and Rural districts due to coronavirus, " Karnataka Minister for Primary and Secondary Education S Suresh Kumar said on Sunday.

According to official estimates, no positive cases of coronavirus have been reported from Karnataka till now.

The state has strengthened all surveillance and containment measures against the possible spread of disease.

Till Sunday, 890 persons have been identified for observation including persons who have travelled to COVID-19 affected countries and contacts of COVID-19 positive cases.

Six persons have been admitted to selected isolation hospitals.

According to official estimates, till date 87,066 passengers have been screened at airports in Karnataka.

The number of COVID-19 cases in India climbed to 39 on Sunday with five people in Kerala testing positive for coronavirus. The deadly virus has caused the deaths of over 3300 people globally.

Bengaluru, Jan 6: A delegation of Christians, led by Peter Machado, archbishop of Bengaluru, met chief minister BS Yediyurappa on Sunday and sought an amicable solution to the issue of installing a statue of Jesus Christ atop Kapalibetta in Harobele village, Kanakapura taluk.

Yediyurappa is learnt to have assured the delegation of doing the needful and said he would take a decision after the revenue department submits its report. The department is looking into various aspects of the issue, including the sanction of 10 acres of land for the purpose.

“The meeting was cordial and the chief minister lent us a patient hearing. Our only request was to settle the issue in a way that is acceptable to all sections of society,” Machado said. Congress functionary and Kanakapura legislator DK Shivakumar had laid the foundation stone for the 114-foot statue of Christ on Kapalibetta on Christmas Day at an event organised by the Harobele Kapalibetta Development Trust, which plans to install the statue.

The issue took a political hue when BJP functionaries objected, saying the land sanctioned to the trust is part of gomala (reserved for cattle grazing) land and any religious activity there would be illegal. Revenue minister R Ashoka sought a report and department officials said they would submit it in a week’s time.