Silk may be used to repair damaged spinal cords: study

Agencies
October 27, 2017

London, Oct 27: Cleaned, sterilised silk from Asian wild silkworms has the properties well suited for spinal cord repair following injury, according to a study.

The modified silk may also have the potential to aid repair following brain injury, researchers said.

Currently there is no cure for serious spinal cord trauma, in part because spinal nerves are unable to cross the scar tissue barrier and the cavity that forms in the cord after the injury.

Researchers from University of Oxford and University of Aberdeen in the UK discovered that modified silk from the Antheraea pernyi (AP) silk spinner had important properties desirable in a scaffold suitable for spinal repair.

The modified silk would be a 'scaffold' that bridges the spinal injury cavity, supporting nerve growth across damaged region, researchers said.

It has the correct rigidity: if it is too rigid it can harm the surrounding spinal cord tissue, but if it is too soft the nerves would fail to grow across it, they said.

The study, published in the journal Scientific Reports, found that AP silk has a repeated 'RGD' chemical sequence on its surface that binds to receptors on the nerve cells, encouraging them to attach to the material and grow along it.

Additionally the silk does not trigger a response by the immune system cells that would be present in the spinal cord, therefore minimising inflammation, researchers said.

The AP silk degrades gradually over time. So, after it has supported the early growth of nerves across the injury site, the material dissolves gradually and these pioneer nerves take over the role as scaffold, supporting further nerve growth, they said.

Spinal injuries affect 250,000500,000 people globally every year. It can have devastating effects for people who suffer them, including loss of motor and sensory function below the level of injury, and bladder, bowel, and sexual dysfunction, researchers said.

"AP silk may also have the potential to aid repair following brain injury," said Wenlong Huang from the University of Aberdeen.

"These are still early bench-based studies but they certainly seem to show that AP silk has fantastic properties, especially suitable for spinal repair, and we look forward to researching this further," Huang said.

This is yet another, and at this stage by far the most important and exciting, example of the value of silks and their derivatives in modern medicine, with its emphasis on using natural regeneration for healing major as well as minor wounds, said Fritz Vollrath from University of Oxford.

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Agencies
June 23,2020

The record levels of new daily COVID-19 cases are due to the fact that the pandemic is peaking in a number of big countries at the same time and reflect a change in the virus' global activity, the World Health Organisation said.

At a media briefing on Monday, WHO's emergencies chief Dr Michael Ryan said that the numbers are increasing because the epidemic is developing in a number of populous countries at the same time.

Some countries have attributed their increased caseload to more testing, including India and the US But Ryan dismissed that explanation.

We do not believe this is a testing phenomenon, he said, noting that numerous countries have also noted marked increases in hospital admissions and deaths neither of which cannot be explained by increased testing.

There definitely is a shift in that the virus is now very well established, Ryan said. The epidemic is now peaking or moving towards a peak in a number of large countries.

He added the situation was definitely accelerating in a number of countries, including the US and others in South Asia, the Middle East and Africa.

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News Network
February 26,2020

New York, Feb 26:  A new wearable sensor that works in conjunction with artificial intelligence (AI) technology could help doctors remotely detect critical changes in heart failure patients days before a health crisis occurs, says a study.

The researchers said the system could eventually help avert up to one in three heart failure readmissions in the weeks following initial discharge from the hospital and help patients sustain a better quality of life.

"This study shows that we can accurately predict the likelihood of hospitalisation for heart failure deterioration well before doctors and patients know that something is wrong," says the study's lead author Josef Stehlik from University of Utah in the US.

"Being able to readily detect changes in the heart sufficiently early will allow physicians to initiate prompt interventions that could prevent rehospitalisation and stave off worsening heart failure," Stehlik added.

According to the researchers, even if patients survive, they have poor functional capacity, poor exercise tolerance and low quality of life after hospitalisations.

"This patch, this new diagnostic tool, could potentially help us prevent hospitalizations and decline in patient status," Stehlik said.

For the findings, published in the journal Circulation: Heart Failure, the researchers followed 100 heart failure patients, average age 68, who were diagnosed and treated at four veterans administration (VA) hospitals in Utah, Texas, California, and Florida.

After discharge, participants wore an adhesive sensor patch on their chests 24 hours a day for up to three months.

The sensor monitored continuous electrocardiogram (ECG) and motion of each subject.

This information was transmitted from the sensor via Bluetooth to a smartphone and then passed on to an analytics platform, developed by PhysIQ, on a secure server, which derived heart rate, heart rhythm, respiratory rate, walking, sleep, body posture and other normal activities.

Using artificial intelligence, the analytics established a normal baseline for each patient. When the data deviated from normal, the platform generated an indication that the patient's heart failure was getting worse.

Overall, the system accurately predicted the impending need for hospitalization more than 80 per cent of the time.

On average, this prediction occurred 10.4 days before a readmission took place (median 6.5 days), the study said.

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Agencies
May 5,2020

The lockdown forced by the coronavirus in India has had some unexpected but positive fallouts: It has brought families together and reduced corporate politics, says an expert working in the field for the past decade.

"Today the whole world is on lockdown because of COVID-19, and all that we read, talk and hear is about life and death. We can't deny that the times are tough and the future is uncertain. But I would like to turn the coin and see the other side: the positive side," Shikha Mittal, Founder Director of Be.artsy told IANS in an interview.

Be.artsy is one of India's leading social awareness enterprises which deals with emotions at work and promotes arts as a communication tool for workplaces.

"In the 21st century, personally and professionally, people are practising politics over humanity, competition over collaboration, and have lost touch with themselves due to materialistic desires. During the lockdown, we are forced to confront our existing daily lives, and two interesting things that we can ponder upon, have emerged.

"First, have we ever looked at our family with the same lens as we are using today? What is it that we are doing differently with family today, and what can we do to carry our actions of today into our tomorrow? This is the premise of the #aajjaisakalcontest" that Be.artsy has launched across India.

The aim is "to encourage people to share one habit or life skill that they never practiced earlier, but post Covid-19 would like to continue and enjoy".

How did Be.artsy come about?

"I used to be in the corporate world, earning promotions and greater responsibility. However, the work conditions in those days were unfriendly to women and I had faced many instances of sexual harassment and workplace harassment in the six years of my corporate career. And that's when I had an epiphany."

Be.artsy's most popular programmes are on Prevention of Sexual Harassment (POSH) and on Financial Literacy which makes young people financially independent and better prepared to face the corporate world. "We know that a stitch in time (of planning for the future) saves nine (debt trap, dependence, health emergencies, expenses exceeding income, no savings, families without support, retirement in poverty, lost dreams, extravagance). This can only be achieved by sensitisation," Mittal explained.

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