Silk may be used to repair damaged spinal cords: study

Agencies
October 27, 2017

London, Oct 27: Cleaned, sterilised silk from Asian wild silkworms has the properties well suited for spinal cord repair following injury, according to a study.

The modified silk may also have the potential to aid repair following brain injury, researchers said.

Currently there is no cure for serious spinal cord trauma, in part because spinal nerves are unable to cross the scar tissue barrier and the cavity that forms in the cord after the injury.

Researchers from University of Oxford and University of Aberdeen in the UK discovered that modified silk from the Antheraea pernyi (AP) silk spinner had important properties desirable in a scaffold suitable for spinal repair.

The modified silk would be a 'scaffold' that bridges the spinal injury cavity, supporting nerve growth across damaged region, researchers said.

It has the correct rigidity: if it is too rigid it can harm the surrounding spinal cord tissue, but if it is too soft the nerves would fail to grow across it, they said.

The study, published in the journal Scientific Reports, found that AP silk has a repeated 'RGD' chemical sequence on its surface that binds to receptors on the nerve cells, encouraging them to attach to the material and grow along it.

Additionally the silk does not trigger a response by the immune system cells that would be present in the spinal cord, therefore minimising inflammation, researchers said.

The AP silk degrades gradually over time. So, after it has supported the early growth of nerves across the injury site, the material dissolves gradually and these pioneer nerves take over the role as scaffold, supporting further nerve growth, they said.

Spinal injuries affect 250,000500,000 people globally every year. It can have devastating effects for people who suffer them, including loss of motor and sensory function below the level of injury, and bladder, bowel, and sexual dysfunction, researchers said.

"AP silk may also have the potential to aid repair following brain injury," said Wenlong Huang from the University of Aberdeen.

"These are still early bench-based studies but they certainly seem to show that AP silk has fantastic properties, especially suitable for spinal repair, and we look forward to researching this further," Huang said.

This is yet another, and at this stage by far the most important and exciting, example of the value of silks and their derivatives in modern medicine, with its emphasis on using natural regeneration for healing major as well as minor wounds, said Fritz Vollrath from University of Oxford.

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Agencies
June 23,2020

The record levels of new daily COVID-19 cases are due to the fact that the pandemic is peaking in a number of big countries at the same time and reflect a change in the virus' global activity, the World Health Organisation said.

At a media briefing on Monday, WHO's emergencies chief Dr Michael Ryan said that the numbers are increasing because the epidemic is developing in a number of populous countries at the same time.

Some countries have attributed their increased caseload to more testing, including India and the US But Ryan dismissed that explanation.

We do not believe this is a testing phenomenon, he said, noting that numerous countries have also noted marked increases in hospital admissions and deaths neither of which cannot be explained by increased testing.

There definitely is a shift in that the virus is now very well established, Ryan said. The epidemic is now peaking or moving towards a peak in a number of large countries.

He added the situation was definitely accelerating in a number of countries, including the US and others in South Asia, the Middle East and Africa.

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Agencies
January 4,2020

Washington D.C., Jan 3: A new study has found out that diet significantly affects the mental health and well being of an individual.

The study was published in the journal European Neuropsychopharmacology.

"We have found that there is increasing evidence of a link between a poor diet and the worsening of mood disorders, including anxiety and depression. However, many common beliefs about the health effects of certain foods are not supported by solid evidence," said the lead researcher, Professor Suzanne Dickson.

According to the researchers, the link between diet and mental health can be firmly established in certain cases like that of the ability of a ketogenic diet being helpful for children with epilepsy and the impact of vitamin B12 deficiency on poor memory, depression and fatigue.

"With individual conditions, we often found very mixed evidence. With ADHD for example, we can see an increase in the quantity of refined sugar in the diet seems to increase ADHD and hyperactivity, whereas eating more fresh fruit and vegetables seems to protect against these conditions," said Dickson

But there are comparatively few studies, and many of them don't last long enough to show long-term effects," added Dickson.

The study further concludes that some food items can be associated with treatment and the betterment of certain mental health conditions.

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Agencies
February 11,2020

Using smartphone for long hours every day may do you more harm than you can probably think of. Researchers have found that spending a lot of time with the device and on social media may lead to mental distress and suicidality among adolescents.

The findings, published in the journal CMAJ (Canadian Medical Association Journal) contains guidance for physicians, parents and teachers on how to help teenagers manage smartphone and social media use for a healthy balance between sleep, academic work, social activity, interpersonal relationships and online activity.

"Physicians, teachers and families need to work together with youth to decrease possible harmful effects of smartphones and social media on their relationships, sense of self, sleep, academic performance, and emotional well-being," said lead author of the study Elia Abi-Jaoude from Toronto Western Hospital in Canada.

This review of evidence, led by the Hospital for Sick Children (SickKids), focuses on smartphone use and does not consider online gaming.

"For adolescents today, who have not known a world without social media, digital interactions are the norm, and the potential benefits of online access to productive mental health information -- including media literacy, creativity, self-expression, sense of belonging and civic engagement -- as well as low barriers to resources such as crisis lines and Internet-based talking therapies cannot be discounted," the authors wrote.

The researchers recommend that doctors should ask teenagers to reduce social media use rather than eradicate it completely and encourage parents to be part of the conversations.

Parents should discuss appropriate smartphone use with teenagers to determine together how to reduce risks and set boundaries.

A recent poll from the US indicates that 54 per cent of teenagers think they spend too much time on their smartphones and about half said they were cutting back on usage.

"Encouragingly, youth are increasingly recognising the negative impact of social media on their lives and starting to take steps to mitigate it," the authors wrote.

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