Suicide bomber kills 96 Yemen soldiers in Sanaa

Melbourne, Apr 10: Scientists have identified six drug candidates from more than 10,000 compounds that may help treat COVID-19.

The research, published in the journal Nature, tested the efficacy of approved drugs, drug candidates in clinical trials and other compounds.

"Currently there are no targeted therapeutics or effective treatment options for COVID-19," said Professor Luke Guddat from the University of Queensland in Australia.

"In order to rapidly discover lead compounds for clinical use, we initiated a programme of high-throughput drug screening, both in laboratories and also using the latest computer software to predict how different drugs bind to the virus," Guddat said.

The project targeted the main COVID-19 virus enzyme, known as the main protease or Mpro, which plays a pivotal role in mediating viral replication, the researchers said.

This makes it an attractive drug target for this virus, and as people don't naturally have this enzyme, compounds that target it are likely to have low toxicity, they said.

"We add the drugs directly to the enzyme or to cell cultures growing the virus and assess how much of each compound is required to stop the enzyme from working or to kill the virus. If the amount is small, then we have a promising compound for further studies," said Guddat.

After assaying thousands of drugs, researchers found of the six that appear to be effective in inhibiting the enzyme, one is of particular interest.

"We're particularly looking at several leads that have been subjected to clinical trials including for the prevention and treatment of various disorders such as cardiovascular diseases, arthritis, stroke, atherosclerosis and cancer," Guddat said.

Researchers said compounds that are already along the pipeline to drug discovery are preferred, as they can be further tested as antivirals at an accelerated rate compared to new drug leads that would have to go through this process from scratch.

"With continued and up-scaled efforts we are optimistic that new candidates can enter the COVID-19 drug discovery pipeline in the near future," Guddat said.

Los Angeles, Apr 30: Los Angeles will begin offering coronavirus">coronavirus testing for free to all citizens regardless of whether they have symptoms, Mayor Eric Garcetti said on Wednesday, adding that LA is the first major US city to take such an initiative.

During the press conference, Garcetti announced that all county residents can now get free coronavirus">coronavirus testing. 

He said the announcement will only apply to city residents for now, but that a similar plan is in development for Los Angeles County,
Garcetti also took to Twitter to announce the same. "Announcing that L.A. is now the first major city in America to offer free COVID-19 testing to all residents. 

While priority will still be given to those with symptoms, individuals without symptoms can also be tested. Sign up at Coronavirus.LACity.org/Testing," he said
Under the new guidelines, priority for the same- or next-day testing will still be given to people with symptoms, such as a fever, cough, and shortness of breath. The free testing will also be prioritized for certain critical frontline workers who interact with the public.

Until now, only residents with symptoms as well as essential workers and those in institutional settings like nursing homes could be tested.

On Wednesday, the LA County reported 1,541 new cases, bringing the total to 22,485 - a seven per cent increase since yesterday.

This includes a backlog of cases that were processed. In the city, there were 683 new cases on Wednesday, bringing the total to 10,380 -- a 7 percent increase since yesterday.

The Hague, Jun 22: Finding inner peace is crucial for the armed forces and yoga is a beautiful way to find the balance, Dutch Defence Minister Ank Bijleveld has said, thanking India for the "wonderful gift" to the world.

Yoga has been gaining global popularity in recent years for the many benefits it has on one's physiology, psychology and spirituality.

Bijleveld participated in the online International Yoga Day celebrations organised by the Indian Embassy here on Sunday.

"The minister thanked India for the wonderful gift of yoga to the world," a statement issued by the embassy said on Monday.

She said finding inner peace is crucial for a man and woman in uniform and yoga is a beautiful way to find the balance, it noted.

Bijleveld said yoga has formed a part of the training for the Dutch armed forces for the last 15 years and there are 130 yoga instructors.

The representatives of the Dutch Army joined by the Dutch Police personnel demonstrated their yoga skills as part of the online celebrations, the statement said.

The sixth International Yoga Day celebrations was streamed to 145,000 followers of the embassy's Facebook, Twitter, Instagram and YouTube channels as well as on its website. It was also streamed on the website of the non-profit foundation Stichting International Yoga Day.

Ambassador of India to The Netherlands Venu Rajamony inaugurated the celebrations. This was followed by Prime Minister Narendra Modi's video message and 3D animated videos of yoga with him.

The event was participated by a host of prominent Dutch and Indian personalities, including Ambassadors of various countries based in The Hague.

Dutch actress Afke Reijenga, extreme sportsman Wim Hof -- popularly known as 'The Iceman' and singers Charlie Dee and Anouk Maas were amongst the Dutch celebrities who participated in the event, the statement said.

Messages and artistic contributions by spiritual leader Sri Sri Ravi Shankar, internationally acclaimed flautist Pandit Hariprasad Chaurasia, violin maestro L Subramaniam, playback singers Kavita Krishnamurthy and Vijay Prakash, chess grandmaster Viswanathan Anand and film stars Raadhika, Sarathkumar and Bhumika Chawla featured in the programme.

Cricketer Suresh Raina, tennis stars Ramesh Krishnan and Rohan Bopanna, yoga guru and artist Bharat Thakur, Olympic ice skater Vishwaraj Jadeja and Michelin star chef Vikas Khanna also featured in the event.

The programme included a Kathak recital on 'Ayush' choreographed by Dutch choreographer Leo Spreksel and performed by eminent Kathak dancers Hari and Chetna with Sirisha.

It also showcased Hollywood and Bollywood celebrities who have made yoga a part of their lives.