Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.
However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.
New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.
The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.
It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.
"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.
As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.
"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.
"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.
To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.
At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.
Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.
In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.
They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.
Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.
The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.
Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.
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Trials of drug dexamethasone in Covid-19 cases have brought success in saving lives , claim Oxford University scientists on 16 June 2020.
According to news reports on 16 June , 2020 , Oxford University Scientists have conducted trials on anti-inflammatory steroid Dexamethasone in Covid-19 cases. Results released by the Oxford University on 16 June 2020 say that the low-cost and easily available drug saves the people seriously infected by Coronavirus , cuts the death risk by a third for those on ventilators and by a fifth for those on oxygen. The commentary on the drug reads like this :-
“ This is a tremendous news today from the recovery trial showing that dexamethasone is the first drug to reduce mortality from Covid-19. It is particularly exciting as this is an inexpensive widely available medicine. This is a ground breaking development in our fight against the disease and the speed at which researchers have progressed finding an effective treatment , is truly remarkable. It shows importance of doing high quality clinical trials and basing decisions as the results of those trials”.
Covid-19 has taken into its grip the entire world during first half of the year 2020 , infecting lacs and killing also lacs of its patients. In the absence of an effective drug or vaccine , people had no choice other than to look up to the heavens or scientists to come with some cure. And the drug described here is the first one to respond to the prayer of the global community , it seems. As regards a vaccine , only few are claiming that it can come by the end of the present year 2020. Rather , some are of the view that it may take a larger part of the year 2021 and could even go to mid-2022. Whatever that scenario about prospect of arrival of vaccine to treat Covid-19 may be , the news that was broken on 16 June 2020 by the Oxford University scientists in relation to drug dexamethasone would have sent a wave of strength and hope among people world-wide. And this Vedic astrology writer was spirited for another reason as well - a prediction of when some relief by way of drug to fight Covid-19 may appear , having come accurate in the claim announced by Oxford University on 16 June 2020. This writer had , based on interpretation and application of Vedic astrology , contributed in early April , 2020 an opinion piece - “ Some searchlight on way out of Covid-19 presently tormenting mankind” - to a number of newspapers. It was also contributed on 11 April , 2020 using the ‘ comments’ column of article -‘ Heard Charles took Ayurveda treatment-based Ayush drugs for Covid-19’ - at theprint.in/india/looking-at-evidence-based-ayush-medicines-to-treat-covid-19-minister-shripad-naik/393407/. The text in the opinion piece related to the claim of success announced by Oxford University scientists on 16 June , 2020 , reads like this :-
“ So reading in between the lines , it can be said that some effective drug or remedy can arrive by mid or towards the last week of June 2020 to provide some relief during July to September 2020 , to some good extent”.
The point this writer wants to share with readers world-wide is that yes , a drug envisaged in the aforesaid prediction has appeared on the horizon in the claim announcement of Oxord University scientists on 16 June , 2020.
Bio :-
Kushal kumar ,
202-GH28 , Mansarovar Apartments ,
Sector 20 , Panchkula-134116 , Haryana,
India.
Note :- This writer’s significant predictive work covering 2020 about the U.S. and Italy
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