Kovind's win victory for poor, downtrodden, marginalised: Amit Shah

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Mangaluru, May 12: Air India will operate two flights - one each from Doha and Muscat - to bring back stranded Kannadigas from Qatar and Oman to Mangaluru next week. 

The flight from Muscat to Mangaluru will be operated on May 20 via Bengaluru. It will depart from Muscat International Airport at 1.15 pm local time and reach Bengaluru at 6.15 pm. After the layover at Bengaluru airport, the flight will take off at 7.15 pm and land at Mangaluru International Airport at around 8.10 pm.

Doha – Bengaluru – Mangaluru flight is will be operated May 22. The flight will take off from Doha at 1.30 pm local time and will land at Bengaluru at 8 pm. It will take off from Bengaluru at 9 pm and land at Mangaluru airport around 9.35 pm.

Kochi, Jan 16: Kicking up a debate, an influential Catholic Church in Kerala has said "Love Jihad is a reality" and alleged that scores of women from Christian community from the southern state were being lured into the trap of Islamic State and used in terror activities.

The synod of Syro-Malabar Church, an apex body of Catholic Bishops chaired by Cardinal George Alencherry, also accused the state police of not viewing the matter cautiously and taking timely action in 'Love Jihad' cases.

Denying the charges, the Popular Front of India (PFI) questioned the "timing" of the statement and urged the Church to withdraw it immediately "as it would only help create division amid growing unity among various sections of society against Hindutva Fascism."

The Viswa Hindu Parishad (VHP) welcomed the Church statement and called for a united fight against 'Love Jihad' in Kerala Society.

An official of the Kerala State Women's Commission refused to comment, considering the sensitivity involved in the matter.

There was no immediate reaction from the police and government as well.

"There are circumstances in which Christian girls are killed in the name of Love Jihad in Kerala," the Synod has alleged in a statement issued through Syro-Malabar Media Commission here on Tuesday night, referring to the attacks against Christians across the world.

The Synod has termed as "shocking" the killing of Christians in Nigeria on Christmas day.

It is a matter of concern that Love Jihad is gaining grounds in Kerala putting in danger its social peace and communal harmony, the Synod said.

"It is a reality that 'Love Jihad' is happening in Kerala in a planned manner targeting Christian girls," it said.

The Synod, referring to a police record, said out of 21 people who were recruited into Islamic State terror outfit, half of them were converted from Christian faith and it should be an eye opener for the community.

Noting that unofficial accounts say many girls were being used in terror activities through Love Jihad, the Synod said it was a serious matter and such accounts state that Love Jihad is not only "in the imagination".

The Synod, however, said it was not assessing the 'Love Jihad' as an issue affecting the friendship between religions and urged the government to treat it as one related to law and order and not as a religious matter.

The Church demanded speedy action against the culprits involved in the 'Love Jihad.'

It also called for efforts to sensitise parents and children about the dangers of Love Jihad.

The PFI, often being accused of playing key roles in alleged 'Love Jihad' cases in Kerala, claimed that the state police, after conducting a thorough probe, had earlier submitted a report in the Kerala High Court, stating that there was no cases of 'Love Jihad' in the state.

"The Church is raising such a baseless allegation at a time when the minorities including Muslims and Christians and the people of Hindu community are in a joint fight against the Fascist government at the Centre.

Their untimely statement would only help divert the people's attention from the key issues that society is facing at present", PFI State President Naziruddin Elamaram told PTI.

Urging the Bishops to immediately withdraw the statement, he said, "I don't know what is their interest in making such a statement at this juncture."

Not a single Muslim community is holding 'Love Jihad' to increase the number of Muslims here, Elamaram claimed.

He, however, said there were instance of inter-religious marriages in Kerala in which Muslim girls marrying Hindu and Christian boys and Hindu and Christian girls selecting partners from the religions of their choice.

Such marriages cannot be termed as 'Love Jihad', he said.

Asked about the Bishops' allegations that Christian girls are targeted and recruited to Islamic State terror outift, the PFI leader said not a single Muslim organisation in India have recognised the Islamic State and such recruitments should not be seen as part of a 'jihad' as doubts prevail in minds on who created the IS.

Former president of the VHP, SJR Kumar claimed that 'Love Jihad' exists in Kerala society.

He alleged that there were centres in Kerala to "convert Hindu and Christian girls who are being lured into the trap of love by youths with criminal backgrounds".

"We have brought this issue into the attention of the Kerala society much earlier. But nobody listened to us.

Now, we are happy that the Bishops have realised the threat of Love Jihad. It is the time of a joint fight against this menace," Kumar told PTI.

He also alleged that Muslim men trap Hindu and Christian women into marriage and forcing them to convert to Islam.

"The converted Hindu and Christian girls are being used in drug trafficking and terrorism," Kumar said.