Scientists find compound to fight virus behind MERS and SARS

June 1, 2014

Geneva, Jun 1: An international team of scientists say they have identified a compound that can fight coronaviruses, responsible for the SARS and MERS outbreaks, which currently have no cure.

MERS and SARSCoronaviruses affected the upper and lower respiratory tracts in humans.

They are the reason for up to a third of common colds.

A more severe strain of the virus, thought to have come from bats, triggered the global SARS (Severe Acute Respiratory Syndrome) epidemic in 2002 that killed nearly 800 people.

The Middle East Respiratory Syndrome (MERS) is a new strain discovered in Saudi Arabia in 2012 and thought to have originated in camels. More deadly but less contageous, it has so far killed 193 people across 636 confirmed cases.

But now a team of scientists led by Edward Trybala from the University of Gothenburg in Sweden, and Volker Thiel from the University of Bern have discovered a compound called K22, which appears to block the ability of the virus to spread in humans.

They first noticed that K22 was able to combat a weak form of coronavirus that causes mild cold-like symptoms, and went on to show that it can fight more serious strains, including SARS and MERS.

In an article for specialist journal "PLOS Pathogens", the scientists explained that the virus reproduces in the cells that line the human respiratory system.

The virus takes over the membranes that separate different parts of human cells, reshaping them into a sort of armour around itself in order to start its production cycle.

But K22 acts at an early stage in this process, preventing the virus from taking control of the cell membranes.

"The results confirm that the use of the membrane of the host cell is a crucial step in the life-cycle of the virus," the researchers wrote.

Their work shows that "the process is highly sensitive and can be influenced by anti-viral medications."

They said the recent SARS epidemic and MERS outbreak mean there should be urgent investment in testing K22 outside the laboratory and developing medicines.

Earlier this month, experts gathered in Geneva by the World Health Organisation confirmed that MERS was spreading but had yet to reach the level of global emergency.

Most of the MERS cases and deaths so far have been in Saudi Arabia, but the virus has been imported to more than a dozen other countries.

All of those cases have involved people who became ill while in the Middle East.

Iran registered its first death from MERS on Thursday, and has registered six cases of the infection.

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Agencies
July 31,2020

Mount Arafat, July 30: Muslim pilgrims converged Thursday on Saudi Arabia's Mount Arafat for the climax of this year's hajj, the smallest in modern times and a sharp contrast to the massive crowds of previous years.

A tight security cordon has been erected all around the foot of the rocky hill outside Mecca, also known as Jabal al-Rahma or Mount of Mercy.

Pilgrims, donning masks and observing social distancing, were brought in buses from neighbouring Mina, state television showed, as Saudi authorities impose measures to prevent a coronavirus outbreak.

They were subject to temperature checks and attended a sermon -- which state media said was translated into 10 languages -- before they set off on the climb to the summit for hours of Koran recitals and prayers to atone for their sins.

The scene was strikingly different to last year's ritual when a sea of pilgrims ascended Mount Arafat, marshalled by tens of thousands of stewards in a bid to prevent any crushes.

After sunset prayers, pilgrims will make their way down Mount Arafat to Muzdalifah, another holy site where they will sleep under the stars to prepare for the final stage of hajj, the symbolic "stoning of the devil".

It takes place on Friday and also marks the beginning of Eid al-Adha, the festival of sacrifice.

The hajj, one of the five pillars of Islam and a must for able-bodied Muslims at least once in their lifetime, is usually one of the world's largest religious gatherings.

But only up to 10,000 people already residing in the kingdom will participate in this year's ritual, compared with 2019's gathering of some 2.5 million from around the world.

"You are not our guests but those of God, the custodian of the two holy mosques (Saudi Arabia's King Salman) and the nation," Hajj Minister Mohammad Benten said in a video released by the media ministry on Wednesday.

Security cordon

A security cordon has been thrown around the holy sites to prevent any security breaches, an interior ministry spokesman said.

Riyadh faced strong criticism in 2015 when some 2,300 worshippers were killed in the deadliest stampede in the gathering's history.

But this year, those risks are greatly reduced by the much smaller crowd.

The pilgrims have all been tested for the virus, and foreign journalists were barred from this year's hajj, usually a huge global media event.

As part of the rites completed over five days in the holy city of Mecca and its surroundings, the pilgrims converged on Mount Arafat after spending the night in Mina.

A district of Mecca, Mina sits in a narrow valley surrounded by rocky mountains, and is transformed each year into a vast encampment for pilgrims.

They began the hajj on Wednesday with their first "tawaf", the circumambulation of the Kaaba, a large structure in Mecca’s Grand Mosque towards which Muslims around the world pray.

The Kaaba is draped in a black cloth embroidered in gold with Koranic verses and known as the kiswa, which is changed each year during the pilgrimage.

Pilgrims were brought inside the mosque in small batches, walking along paths marked on the floor, in sharp contrast to the normal sea of humanity that swirls around the Kaaba during hajj.

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News Network
April 27,2020

Dubai, Apr 27: Saudi Arabia has reported 1,289 new Covid-19 cases on April 27, its Ministry of Health tweeted.

Of the newly diagnosed cases, Jeddah recorded 294 infections, followed by Makkah (218) and Madinah (202).

The ministry also confirmed five additional coronavirus-induced deaths, spiking the total death toll to 144.

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Since the outbreak of the virus strain in the Chinese city of Wuhan late last year, Saudi Arabia has reported a total of 18,811 Covid-19 infections.

As many as 2,531 patients have till now recovered from the virus.

Oman
The sultanate registered 51 new Covid-19 cases on April 27, including 37 nationals and 14 expatriates, spiking the total number of infections to 2,049, Oman News Agency tweeted.

Meanwhile, 10 coronavirus-related deaths have been confirmed in the country.

Qatar
The Ministry of Public Health has reported 957 Covid-19 cases among the 3,420 people tested in the last 24 hours.

As many as 85,709 people have been tested for the virus across the country.

The total number of Covid-19 infections since the outbreak has now risen to 11,244.

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Agencies
June 22,2020

Riyadh, Jun 22: The Ministry of Municipal and Rural Affairs (MMRA) in Saudi Arabia has announced the continuation of the ban on providing Shisha (hubble-bubble), and the closure of children's play areas in restaurants as a precautionary measure for protecting the health of citizens and residents from the novel coronavirus COVID-19 infection.

The new stage, in which the Kingdom is beginning to coexist with the virus, focuses on the concept of "social distancing" that has emerged since the start of the coronavirus crisis throughout the world,

It stipulates leaving at least 2 meters between one person and the other in public places to prevent the transmission of infection, in addition to covering the mouth and nose by wearing a facemask.

It also specifies complying with the preventive protocols in workplaces, stores, shops, mosques and tourist attractions, with human gatherings not to exceed 50 people, as a maximum.

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